Targeting amplified MYCN through CDK7 inhibition in high-risk neuroblastoma

被引：0
|
作者：
George, Rani [1 ]
机构：
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
CANCER RESEARCH | 2016年 / 76卷
关键词：
D O I：
10.1158/1538-7445.PEDCA15-IA21
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
IA21
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Effect of CDK7 inhibitor on MYCN-amplified retinoblastoma
    Xu, Hanyue
    Xiao, Lirong
    Chen, Yi
    Liu, Yilin
    Zhang, Yifan
    Gao, Yuzhu
    Man, Shulei
    Yan, Naihong
    Zhang, Ming
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2023, 1866 (03):
  • [2] Selective inhibition of CDK7 targets MYCN-driven transcriptional amplification in neuroblastoma
    Chipumuro, Edmond
    Marco, Eugenio
    Zhang, Tinghu
    Christensen, Camilla
    Kwiatkowski, Nicholas
    Sharma, Bandana
    Hatheway, Clark
    Altabef, Abigail
    Abraham, Brian J.
    Wong, Kwok-Kin
    Yuan, Guo-Cheng
    Young, Richard A.
    Gray, Nathanael S.
    George, Rani E.
    CANCER RESEARCH, 2014, 74 (19)
  • [3] TARGETING TRANSCRIPTIONAL ADDICTION FOR GBM THERAPY THROUGH CDK7 INHIBITION
    Meng, Wei
    Wang, Jiajia
    Li, Qifeng
    Liu, Fang
    Li, Meng
    Jiang, Wenyan
    Lin, Li
    Dai, Xiaomin
    Wang, Hongxiang
    Zhang, Chenran
    Wang, Baocheng
    Chen, Juxiang
    Zhang, Liye
    Tang, Yujie
    Ma, Jie
    NEURO-ONCOLOGY, 2018, 20 : 180 - 180
  • [4] Targeting of CDK7 inhibits super-enhancer-associated oncogenic programs in MYCN-amplified tumor cells
    Chipumuro, Edmond
    Marco, Eugenio
    Christensen, Camilla L.
    Kwiatkowski, Nicholas
    Zhang, Tinghu
    Hatheway, Clark M.
    Abraham, Brian J.
    Sharma, Bandana
    Yeung, Caleb
    Altabef, Abigail
    Perez-Atayde, Antonio
    Wong, Kwok-Kin
    Yuan, Guo-Cheng
    Gray, Nathanael S.
    Young, Richard A.
    George, Rani E.
    MOLECULAR CANCER RESEARCH, 2015, 13
  • [5] Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13
    Zeng, Mei
    Kwiatkowski, Nicholas P.
    Zhang, Tinghu
    Nabet, Behnam
    Xu, Mousheng
    Liang, Yanke
    Quan, Chunshan
    Wang, Jinhua
    Hao, Mingfeng
    Palakurthi, Sangeetha
    Zhou, Shan
    Zeng, Qing
    Kirschmeier, Paul T.
    Meghani, Khyati
    Leggett, Alan L.
    Qi, Jun
    Shapiro, Geoffrey I.
    Liu, Joyce F.
    Matulonis, Ursula A.
    Lin, Charles Y.
    Konstantinopoulos, Panagiotis A.
    Gray, Nathanael S.
    ELIFE, 2018, 7
  • [6] CDK7 INHIBITION IN AT/RT
    Morin, Andrew
    Veo, Bethany
    Fosmire, Susan
    Crespo, Michele
    Zahedi, Shadi
    Vibhakar, Rajeev
    Levy, Jean M. Mulcahy
    NEURO-ONCOLOGY, 2020, 22 : 279 - 280
  • [7] CDK7 INHIBITION IN AT/RT
    Morin, Andrew
    Wodetzki, Darya
    Veo, Bethany
    Pierce, Angela
    Zahedi, Shadi
    Crespo, Michele
    Venkataraman, Sujatha
    Vibhakar, Rajeev
    Mulcahy-Levy, Jean
    NEURO-ONCOLOGY, 2022, 24 : 8 - 8
  • [8] Temozolomide (TMZ) and Irinotecan (IRN) as a Maintenance Therapy for MYCN Non-Amplified High-Risk Neuroblastoma
    Isshiki, Kyohei
    Kiyotani, Chikako
    Matsukawa, Yukihiro
    Sugawa, Masahiro
    Mizuno, Takanori
    Tsujimoto, Shinnichi
    Sakamoto, Kennichi
    Uchiyama, Meri
    Osumi, Tomoo
    Shioda, Yoko
    Kato, Motohiro
    Terashima, Keita
    Tomizawa, Daisuke
    Hishiki, Tomoro
    Yoshioka, Takako
    Fuji, Hiroshi
    Miyazaki, Osamu
    Kitamura, Masayuki
    Matsumoto, Kimikazu
    PEDIATRIC BLOOD & CANCER, 2019, 66 : S107 - S108
  • [9] Identification and validation of a novel five-gene signature in high-risk MYCN-not-amplified neuroblastoma
    Wang, Jin-Xia
    Zhang, Hong-Yang
    Yan, Zi-Jun
    Cao, Zi-Yang
    Shao, Jing-Bo
    Zou, Lin
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [10] A Double-Conditioning Regimen with Thiotepa and Melphalan is Effective for MYCN-Amplified High-Risk Neuroblastoma
    Yamazaki, F.
    Kiyotani, C.
    Yamasaki, K.
    Nitani, C.
    Okada, K.
    Fujisaki, H.
    Shioda, Y.
    Hara, J.
    Matsumoto, K.
    PEDIATRIC BLOOD & CANCER, 2017, 64 : S240 - S240
12345