Age-related changes of mitochondrial cytochrome C oxidase and F-0-F-1-ATP synthase subunit contents in rat cerebral cortex

被引:0
作者
Nicoletti, VG [1 ]
Tendi, EA [1 ]
Lalicata, C [1 ]
Reale, S [1 ]
Villa, RF [1 ]
Ragusa, N [1 ]
GiuffridaStella, AM [1 ]
机构
[1] UNIV PAVIA,FAC SCI,INST PHARMACOL,I-27100 PAVIA,ITALY
关键词
cytochrome c oxidase; F0F1-ATP synthase; inner mitochondrial membrane;
D O I
暂无
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The levels of subunits I, II/III, and IV of cytochrome c oxidase and of subunits alpha, beta and gamma of F0F1-ATP synthase in inner mitochondrial membrane proteins purified from cerebral cortex of rat at 2, 6, 12, 18, 24, 26 months of age were analyzed by Western blot. Age-related changes in the content of subunits, encoded either in mitochondrial or nuclear DNA, were observed.
引用
收藏
页码:509 / 513
页数:5
相关论文
共 17 条
[1]   SEQUENTIAL DAMAGE IN MITOCHONDRIAL COMPLEXES BY PEROXIDATIVE STRESS [J].
BENZI, G ;
CURTI, D ;
PASTORIS, O ;
MARZATICO, F ;
VILLA, RF ;
DAGANI, F .
NEUROCHEMICAL RESEARCH, 1991, 16 (12) :1295-1302
[2]  
BOLANOS JP, 1994, J NEUROCHEM, V63, P910
[3]   AGE-DEPENDENT IMPAIRMENT OF MITOCHONDRIAL-FUNCTION IN PRIMATE BRAIN [J].
BOWLING, AC ;
MUTISYA, EM ;
WALKER, LC ;
PRICE, DL ;
CORK, LC ;
BEAL, MF .
JOURNAL OF NEUROCHEMISTRY, 1993, 60 (05) :1964-1967
[4]   AGE-RELATED MODIFICATIONS OF CYTOCHROME-C-OXIDASE ACTIVITY IN DISCRETE BRAIN-REGIONS [J].
CURTI, D ;
GIANGARE, MC ;
REDOLFI, ME ;
FUGACCIA, I ;
BENZI, G .
MECHANISMS OF AGEING AND DEVELOPMENT, 1990, 55 (02) :171-180
[5]   MITOCHONDRIAL-DNA COPY NUMBER AND MITOCHONDRIAL-DNA DELETION IN ADULT AND SENESCENT RATS [J].
GADALETA, MN ;
RAINALDI, G ;
LEZZA, AMS ;
MILELLA, F ;
FRACASSO, F ;
CANTATORE, P .
MUTATION RESEARCH, 1992, 275 (3-6) :181-193
[6]   DETECTION OF INACTIVE ENZYME MOLECULES IN AGEING ORGANISMS [J].
GERSHON, H ;
GERSHON, D .
NATURE, 1970, 227 (5264) :1214-&
[7]   AN INTEGRATED THEORY OF AGING AS THE RESULT OF MITOCHONDRIAL-DNA MUTATION IN DIFFERENTIATED CELLS [J].
MIQUEL, J .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1991, 12 (2-3) :99-117
[8]   A 2-STEP HYPOTHESIS ON THE MECHANISMS OF INVITRO-CELL AGING - CELL-DIFFERENTIATION FOLLOWED BY INTRINSIC MITOCHONDRIAL MUTAGENESIS [J].
MIQUEL, J ;
FLEMING, JE .
EXPERIMENTAL GERONTOLOGY, 1984, 19 (01) :31-36
[9]  
NAGY K, 1983, BIOCHEM BIOPH RES CO, V117, P586
[10]   AGE-RELATED-CHANGES IN THE ACTIVITY OF THE PYRUVATE CARRIER AND IN THE LIPID-COMPOSITION IN RAT-HEART MITOCHONDRIA [J].
PARADIES, G ;
RUGGIERO, FM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1016 (02) :207-212