The Link Between the Microbiota and HER2+Breast Cancer: The New Challenge of Precision Medicine

被引：14

作者：

Di Modica, Martina ^{[1
]}

Arlotta, Valeria ^{[1
]}

Sfondrini, Lucia ^{[1
,2
]}

Tagliabue, Elda ^{[1
]}

Triulzi, Tiziana ^{[1
]}

机构：

[1] Fdn Ist Ricovero & Cura Carattere Sci IRCCS Ist Na, Mol Targeting Unit, Dept Res, Milan, Italy

[2] Univ Milan, Dipartimento Sci Biomed Salute, Milan, Italy

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

microbiota; HER2; neu; targeted therapy; breast cancer; precision medicine; MALE BREAST-CANCER; IMMUNE-SYSTEM; INTESTINAL MICROBIOTA; TUMOR; CONSUMPTION; TISSUE; CHEMOTHERAPY; ASSOCIATION; MODULATE; GROWTH;

D O I：

10.3389/fonc.2022.947188

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The microbiota is emerging as a key player in cancer due to its involvement in several host physiological functions, including digestion, development of the immune system, and modulation of endocrine function. Moreover, its participation in the efficacy of anticancer treatments has been well described. For instance, the involvement of the breast microbiota in breast cancer (BC) development and progression has gained ground in the past several years. In this review, we report and discuss new findings on the impact of the gut and breast microbiota on BC, focusing on the HER2+ BC subtype, and the possibility of defining microbial signatures that are associated with disease aggressiveness, treatment response, and therapy toxicity. We also discuss novel insights into the mechanisms through which microorganism-host interactions occur and the possibility of microbiota editing in the prevention and treatment optimization of BC.

引用

页数：14

共 128 条

[1] Intestinal Microbiota in Postmenopausal Breast Cancer Patients and Controls [J].

Aarnoutse, Romy ;

Hillege, Lars E. ;

Ziemons, Janine ;

De Vos-Geelen, Judith ;

de Boer, Maaike ;

Aerts, Elvira M. E. R. ;

Vriens, Birgit E. P. J. ;

van Riet, Yvonne ;

Vincent, Jeroen ;

van de Wouw, Agnes J. ;

Le, Giang N. ;

Venema, Koen ;

Rensen, Sander S. ;

Penders, John ;

Smidt, Marjolein L. .

CANCERS, 2021, 13 (24)

[2] Microbiota modulate Doxorubicin induced cardiotoxicity [J].

An, Lulu ;

Wuri, Jimusi ;

Zheng, Zhitong ;

Li, Wenqui ;

Yan, Tao .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 166

[3] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[4] The administration of milk fermented by the probiotic Lactobacillus casei CRL 431 exerts an immunomodulatory effect against a breast tumour in a mouse model [J].

Aragon, Felix ;

Carino, Silvia ;

Perdigon, Gabriela ;

de Moreno de LeBlanca, Alejandra .

IMMUNOBIOLOGY, 2014, 219 (06) :457-464

[5] The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL [J].

Aykut, Berk ;

Pushalkar, Smruti ;

Chen, Ruonan ;

Li, Qianhao ;

Abengozar, Raquel ;

Kim, Jacqueline I. ;

Shadaloey, Sorin A. ;

Wu, Dongling ;

Preiss, Pamela ;

Verma, Narendra ;

Guo, Yuqi ;

Saxena, Anjana ;

Vardhan, Mridula ;

Diskin, Brian ;

Wang, Wei ;

Leinwand, Joshua ;

Kurz, Emma ;

Rossi, Juan A. Kochen ;

Hundeyin, Mautin ;

Zambrinis, Constantinos ;

Li, Xin ;

Saxena, Deepak ;

Miller, George .

NATURE, 2019, 574 (7777) :264-+

[6] Mutagenesis by Microbe: the Role of the Microbiota in Shaping the Cancer Genome [J].

Barrett, Maurice ;

Hand, Collette K. ;

Shanahan, Fergus ;

Murphy, Thomas ;

O'Toole, Paul W. .

TRENDS IN CANCER, 2020, 6 (04) :277-287

[7] Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients [J].

Baruch, Erez N. ;

Youngster, Ilan ;

Ben-Betzalel, Guy ;

Ortenberg, Rona ;

Lahat, Adi ;

Katz, Lior ;

Adler, Katerina ;

Dick-Necula, Daniela ;

Raskin, Stephen ;

Bloch, Naamah ;

Rotin, Daniil ;

Anafi, Liat ;

Avivi, Camila ;

Melnichenko, Jenny ;

Steinberg-Silman, Yael ;

Mamtani, Ronac ;

Harati, Hagit ;

Asher, Nethanel ;

Shapira-Frommer, Ronnie ;

Brosh-Nissimov, Tal ;

Eshet, Yael ;

Ben-Simon, Shira ;

Ziv, Oren ;

Khan, Md Abdul Wadud ;

Amit, Moran ;

Ajami, Nadim J. ;

Barshack, Iris ;

Schachter, Jacob ;

Wargo, Jennifer A. ;

Koren, Omry ;

Markel, Gal ;

Boursi, Ben .

SCIENCE, 2021, 371 (6529) :602-+

[8] Mediterranean Diet and Its Association With Reduced Invasive Breast Cancer Risk [J].

Berrino, Franco .

JAMA ONCOLOGY, 2016, 2 (04) :535-536

[9] The immune system and response to HER2-targeted treatment in breast cancer [J].

Bianchini, Giampaolo ;

Gianni, Luca .

LANCET ONCOLOGY, 2014, 15 (02) :E58-E68

[10] Faecal Microbiota Composition Varies between Patients with Breast Cancer and Healthy Women: A Comparative Case-Control Study [J].

Bobin-Dubigeon, Christine ;

Luu, Huyen Trang ;

Leuillet, Sebastien ;

Lavergne, Sidonie N. ;

Carton, Thomas ;

Le Vacon, Francoise ;

Michel, Catherine ;

Nazih, Hassane ;

Bard, Jean-Marie .

NUTRIENTS, 2021, 13 (08)

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