Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors

被引：29
|
作者：
Naureen, Sadia [1 ]
Noreen, Shazia [2 ]
Nazeer, Areesha [1 ]
Ashraf, Muhammad [3 ]
Alam, Umber [3 ]
Munawar, Munawar Ali [1 ]
Khan, Misbahul Ain [1 ,2 ]
机构：
[1] Univ Punjab, Inst Chem, Lahore, Pakistan
[2] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur 63100, Pakistan
[3] Islamia Univ Bahawalpur, Dept Biochem & Biotechnol, Bahawalpur 63100, Pakistan
来源：
MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 04期
关键词：
Multicomponent reactions; Benzil; Fisher indole synthesis; NMR spectra;
D O I：
10.1007/s00044-014-1239-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new trisubstituted imidazoles-3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives (2a-2u) were synthesized and evaluated for their alpha-glucosidase inhibition. The new compounds showed significant alpha-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined using FT-IR, Mass spectrometry, H-1 NMR, C-13 NMR, and elemental analyses.
引用
收藏
页码：1586 / 1595
页数：10
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