Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors

被引：29

作者：

Naureen, Sadia ^{[1
]}

Noreen, Shazia ^{[2
]}

Nazeer, Areesha ^{[1
]}

Ashraf, Muhammad ^{[3
]}

Alam, Umber ^{[3
]}

Munawar, Munawar Ali ^{[1
]}

Khan, Misbahul Ain ^{[1
,2
]}

机构：

[1] Univ Punjab, Inst Chem, Lahore, Pakistan

[2] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur 63100, Pakistan

[3] Islamia Univ Bahawalpur, Dept Biochem & Biotechnol, Bahawalpur 63100, Pakistan

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 04期

关键词：

Multicomponent reactions; Benzil; Fisher indole synthesis; NMR spectra;

D O I：

10.1007/s00044-014-1239-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new trisubstituted imidazoles-3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives (2a-2u) were synthesized and evaluated for their alpha-glucosidase inhibition. The new compounds showed significant alpha-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined using FT-IR, Mass spectrometry, H-1 NMR, C-13 NMR, and elemental analyses.

引用

页码：1586 / 1595

页数：10

共 23 条

[1] Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus [J].