Latest international guidelines for screening, prevention and treatment of familial breast cancer - implications for the relevant practice in Hungary

被引：0

作者：

Laszlo, Romics ^{[1
]}

Judit, Kocsis ^{[2
]}

Katalin, Ormandi ^{[3
]}

Akos, Molnar Bela ^{[4
]}

机构：

[1] Queen Elizabeth Univ Hosp, New Victoria Hosp, Glasgow, Lanark, Scotland

[2] Debreceni Egyet, Altalanos Orvostudomanyi Kar, Onkol Intezet, Klin Kozpont, Debrecen, Hungary

[3] Szegedi Tudomanyegyetem, Altalanos Orvostudomanyi Kar, Radiol Klin, Diagnoscan Magyarorszag Kft, Szeged, Hungary

[4] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Sebeszeti Klin 1, Budapest, Hungary

来源：

ORVOSI HETILAP | 2016年 / 157卷 / 28期

关键词：

breast cancer; familial; management; guideline; PROPHYLACTIC BILATERAL MASTECTOMY; BRCA2; MUTATIONS; FOLLOW-UP; RISK; WOMEN; MAMMOGRAPHY; TAMOXIFEN; VARIANTS; UPDATE; COHORT;

D O I：

10.1556/650.2016.30473

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Screening, prevention and treatment of familial breast cancer require a multidisciplinary approach. New guidelines were published in the United Kingdom for the management of familial breast cancer. Aim: The authors summarise these new guidelines and analyse the relevant practice in Hungary. Method: Relevant guidelines of the National Institute for Health and Care Excellence and Familial Breast Cancer Report (NHS Scotland) are described. Results: New guidelines will increase the number of genetic tests as well as genetic counselling. An increase in the number of breast magnetic resonance imaging is expected, too. Chemoprevention can be offered for individuals with medium risk and above. Promising trials are underway with platinum based chemotherapy and polyADP-ribose polimerase inhibitors for the systemic treatment of familial breast cancer. The increase in the number of genetic tests, counselling, and breast magnetic resonance imaging may have a significant impact on health care budget. Conclusions: These guidelines will change some aspects of the current management of familial breast cancer.

引用

页码：1117 / 1125

页数：9

共 52 条

[1] Pregnancies, breast-feeding, and breast cancer risk in the international BRCA1/2 carrier cohort study (IBCCS) [J].

Andrieu, Nadine ;

Goldgar, David E. ;

Easton, Douglas F. ;

Rookus, Matti ;

Brohet, Richard ;

Antoniou, Antonis C. ;

Peock, Susan ;

Evans, Gareth ;

Eccles, Diana ;

Douglas, Fiona ;

Nogues, Catherine ;

Gauthier-Villars, Marion ;

Chompret, Agnes ;

van Leeuwen, Flora E. ;

Kluijt, Irina ;

Benitez, Javier ;

Arver, Brita ;

Olah, Edith ;

Chang-Claude, Jenny .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (08) :535-544

[2] PARP Inhibitor Treatment in Ovarian and Breast Cancer [J].

不详 .

CURRENT PROBLEMS IN CANCER, 2011, 35 (01) :7-50

[3]

[Anonymous], 2014, FAM BREAST CANC REP

[4] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history:: A combined analysis of 22 studies [J].

Antoniou, A ;

Pharoah, PDP ;

Narod, S ;

Risch, HA ;

Eyfjord, JE ;

Hopper, JL ;

Loman, N ;

Olsson, H ;

Johannsson, O ;

Borg, Å ;

Pasini, B ;

Radice, P ;

Manoukian, S ;

Eccles, DM ;

Tang, N ;

Olah, E ;

Anton-Culver, H ;

Warner, E ;

Lubinski, J ;

Gronwald, J ;

Gorski, B ;

Tulinius, H ;

Thorlacius, S ;

Eerola, H ;

Nevanlinna, H ;

Syrjäkoski, K ;

Kallioniemi, OP ;

Thompson, D ;

Evans, C ;

Peto, J ;

Lalloo, F ;

Evans, DG ;

Easton, DF .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) :1117-1130

[5] The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions [J].

Antoniou, A. C. ;

Cunningham, A. P. ;

Peto, J. ;

Evans, D. G. ;

Lalloo, F. ;

Narod, S. A. ;

Risch, H. A. ;

Eyfjord, J. E. ;

Hopper, J. L. ;

Southey, M. C. ;

Olsson, H. ;

Johannsson, O. ;

Borg, A. ;

Passini, B. ;

Radice, P. ;

Manoukian, S. ;

Eccles, D. M. ;

Tang, N. ;

Olah, E. ;

Anton-Culver, H. ;

Warner, E. ;

Lubinski, J. ;

Gronwald, J. ;

Gorski, B. ;

Tryggvadottir, L. ;

Syrjakoski, K. ;

Kallioniemi, O-P ;

Eerola, H. ;

Nevanlinna, H. ;

Pharoah, P. D. P. ;

Easton, D. F. .

BRITISH JOURNAL OF CANCER, 2008, 98 (08) :1457-1466

[6]

Baselga J, 2010, ANN ONCOL, V21

[7] Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer [J].

Bojesen, Stig E. ;

Pooley, Karen A. ;

Johnatty, Sharon E. ;

Beesley, Jonathan ;

Michailidou, Kyriaki ;

Tyrer, Jonathan P. ;

Edwards, Stacey L. ;

Pickett, Hilda A. ;

Shen, Howard C. ;

Smart, Chanel E. ;

Hillman, Kristine M. ;

Mai, Phuong L. ;

Lawrenson, Kate ;

Stutz, Michael D. ;

Lu, Yi ;

Karevan, Rod ;

Woods, Nicholas ;

Johnston, Rebecca L. ;

French, Juliet D. ;

Chen, Xiaoqing ;

Weischer, Maren ;

Nielsen, Sune F. ;

Maranian, Melanie J. ;

Ghoussaini, Maya ;

Ahmed, Shahana ;

Baynes, Caroline ;

Bolla, Manjeet K. ;

Wang, Qin ;

Dennis, Joe ;

McGuffog, Lesley ;

Barrowdale, Daniel ;

Lee, Andrew ;

Healey, Sue ;

Lush, Michael ;

Tessier, Daniel C. ;

Vincent, Daniel ;

Bacot, Francis ;

Vergote, Ignace ;

Lambrechts, Sandrina ;

Despierre, Evelyn ;

Risch, Harvey A. ;

Gonzalez-Neira, Anna ;

Rossing, Mary Anne ;

Pita, Guillermo ;

Doherty, Jennifer A. ;

Alvarez, Nuria ;

Larson, Melissa C. ;

Fridley, Brooke L. ;

Schoof, Nils ;

Chang-Claude, Jenny .

NATURE GENETICS, 2013, 45 (04) :371-384

[8] Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients [J].

Byrski, T. ;

Huzarski, T. ;

Dent, R. ;

Marczyk, E. ;

Jasiowka, M. ;

Gronwald, J. ;

Jakubowicz, J. ;

Cybulski, C. ;

Wisniowski, R. ;

Godlewski, D. ;

Lubinski, J. ;

Narod, S. A. .

BREAST CANCER RESEARCH AND TREATMENT, 2014, 147 (02) :401-405

[9] ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2) [J].

Cardoso, F. ;

Costa, A. ;

Norton, L. ;

Senkus, E. ;

Aapro, M. ;

Andre, F. ;

Barrios, C. H. ;

Bergh, J. ;

Biganzoli, L. ;

Blackwell, K. L. ;

Cardoso, M. J. ;

Cufer, T. ;

El Saghir, N. ;

Fallowfield, L. ;

Fenech, D. ;

Francis, P. ;

Gelmon, K. ;

Giordano, S. H. ;

Gligorov, J. ;

Goldhirsch, A. ;

Harbeck, N. ;

Houssami, N. ;

Hudis, C. ;

Kaufman, B. ;

Krop, I. ;

Kyriakides, S. ;

Lin, U. N. ;

Mayer, M. ;

Merjaver, S. D. ;

Nordstrom, E. B. ;

Pagani, O. ;

Partridge, A. ;

Penault-Llorca, F. ;

Piccart, M. J. ;

Rugo, H. ;

Sledge, G. ;

Thomssen, C. ;

van't Veer, L. ;

Vorobiof, D. ;

Vrieling, C. ;

West, N. ;

Xu, B. ;

Winer, E. .

BREAST, 2014, 23 (05) :489-502

[10] Long-term results of tamoxifen prophylaxis for breast cancer-96-month follow-up of the randomized IBIS-I trial [J].

Cuzick, Jack ;

Forbes, John F. ;

Sestak, Ivana ;

Cawthorn, Simon ;

Hamed, Hisham ;

Holli, Kaija ;

Howell, Anthony .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (04) :272-282

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