C-elegans as a model in developmental neurotoxicology

被引：89

作者：

Ruszkiewicz, Joanna A. ^{[1
]}

Pinkas, Adi ^{[1
]}

Miah, Mahfuzur R. ^{[1
]}

Weitz, Rebecca L. ^{[1
]}

Lawes, Michael J. A. ^{[1
]}

Akinyemi, Ayodele J. ^{[1
,2
]}

Ijomone, Omamuyovwi M. ^{[1
,3
]}

Aschner, Michael ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10467 USA

[2] Afe Babalola Univ, Dept Biochem, Ado Ekiti, Ekiti State, Nigeria

[3] Fed Univ Technol Akure, Sch Hlth & Hlth Technol, Dept Anat, Akure, Nigeria

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 2018年 / 354卷

基金：

美国国家卫生研究院;

关键词：

Neurodevelopment; Neurotoxicity; C; elegans; Manganese; Mercury; Pesticides; ETHYLENE-BIS-DITHIOCARBAMATE; MANGANESE-INDUCED NEUROTOXICITY; DOPAMINE NEURON DEGENERATION; LEVEL ARSENIC EXPOSURE; MN-INDUCED TOXICITY; CAENORHABDITIS-ELEGANS; OXIDATIVE STRESS; ORGANOPHOSPHORUS INSECTICIDE; PARKINSONS-DISEASE; NERVOUS-SYSTEM;

D O I：

10.1016/j.taap.2018.03.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Due to many advantages Caenorhabditis elegans (C. elegans) has become a preferred model of choice in many fields, including neurodevelopmental toxicity studies. This review discusses the benefits of using C. elegans as an alternative to mammalian systems and gives examples of the uses of the nematode in evaluating the effects of major known neurodevelopmental toxins, including manganese, mercury, lead, fluoride, arsenic and organophosphorus pesticides. Reviewed data indicates numerous similarities with mammals in response to these toxins. Thus, C. elegans studies have the potential to predict possible effects of developmental neurotoxicants in higher animals, and may be used to identify new molecular pathways behind neurodevelopmental disruptions, as well as new toxicants.

引用

页码：126 / 135

页数：10

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