C-elegans as a model in developmental neurotoxicology

被引：89

作者：

Ruszkiewicz, Joanna A. ^{[1
]}

Pinkas, Adi ^{[1
]}

Miah, Mahfuzur R. ^{[1
]}

Weitz, Rebecca L. ^{[1
]}

Lawes, Michael J. A. ^{[1
]}

Akinyemi, Ayodele J. ^{[1
,2
]}

Ijomone, Omamuyovwi M. ^{[1
,3
]}

Aschner, Michael ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10467 USA

[2] Afe Babalola Univ, Dept Biochem, Ado Ekiti, Ekiti State, Nigeria

[3] Fed Univ Technol Akure, Sch Hlth & Hlth Technol, Dept Anat, Akure, Nigeria

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 2018年 / 354卷

基金：

美国国家卫生研究院;

关键词：

Neurodevelopment; Neurotoxicity; C; elegans; Manganese; Mercury; Pesticides; ETHYLENE-BIS-DITHIOCARBAMATE; MANGANESE-INDUCED NEUROTOXICITY; DOPAMINE NEURON DEGENERATION; LEVEL ARSENIC EXPOSURE; MN-INDUCED TOXICITY; CAENORHABDITIS-ELEGANS; OXIDATIVE STRESS; ORGANOPHOSPHORUS INSECTICIDE; PARKINSONS-DISEASE; NERVOUS-SYSTEM;

D O I：

10.1016/j.taap.2018.03.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Due to many advantages Caenorhabditis elegans (C. elegans) has become a preferred model of choice in many fields, including neurodevelopmental toxicity studies. This review discusses the benefits of using C. elegans as an alternative to mammalian systems and gives examples of the uses of the nematode in evaluating the effects of major known neurodevelopmental toxins, including manganese, mercury, lead, fluoride, arsenic and organophosphorus pesticides. Reviewed data indicates numerous similarities with mammals in response to these toxins. Thus, C. elegans studies have the potential to predict possible effects of developmental neurotoxicants in higher animals, and may be used to identify new molecular pathways behind neurodevelopmental disruptions, as well as new toxicants.

引用

页码：126 / 135

页数：10

共 149 条

[101] Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation [J].

Peixoto, F .

CHEMOSPHERE, 2005, 61 (08) :1115-1122

[102] COMPARATIVE-STUDY ON THE CHANGES IN ACHE AND ATPASE ACTIVITIES IN NEONATE AND ADULT-RAT BRAINS UNDER THIOBENCARB STRESS [J].

PENTYALA, SN ;

CHETTY, CS .

JOURNAL OF APPLIED TOXICOLOGY, 1993, 13 (01) :39-42

[103] Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies [J].

Peres, Tanara V. ;

Schettinger, Maria Rosa C. ;

Chen, Pan ;

Carvalho, Fabiano ;

Avila, Daiana S. ;

Bowman, Aaron B. ;

Aschner, Michael .

BMC PHARMACOLOGY & TOXICOLOGY, 2016, 17

[104] Developmental exposure to manganese induces lasting motor and cognitive impairment in rats [J].

Peres, Tanara V. ;

Eyng, Helena ;

Lopes, Samantha C. ;

Colle, Dirleise ;

Goncalves, Filipe M. ;

Venske, Debora K. R. ;

Lopes, Mark W. ;

Ben, Juliana ;

Bornhorst, Julia ;

Schwerdtle, Tanja ;

Aschner, Michael ;

Farina, Marcelo ;

Prediger, Rui D. ;

Leal, Rodrigo B. .

NEUROTOXICOLOGY, 2015, 50 :28-37

[105] Use of non-mammalian alternative models for neurotoxicological study [J].

Peterson, Randall T. ;

Nass, Richard ;

Boyd, Windy A. ;

Freedman, Jonathan H. ;

Dong, Ke ;

Narahashi, Toshio .

NEUROTOXICOLOGY, 2008, 29 (03) :546-555

[106] Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study [J].

Rahman, Syed Moshfiqur ;

Kippler, Maria ;

Tofail, Fahmida ;

Bolte, Sven ;

Hamadani, Jena Derakhshani ;

Vahter, Marie .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2017, 125 (05)

[107] Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats [J].

Ranpariya, V. L. ;

Parmar, S. K. ;

Sheth, N. R. ;

Chandrashekhar, V. M. .

PHARMACEUTICAL BIOLOGY, 2011, 49 (07) :696-701

[108]

Rice Kevin M, 2014, J Prev Med Public Health, V47, P74, DOI 10.3961/jpmph.2014.47.2.74

[109] Worms under stress: C. elegans stress response and its relevance to complex human disease and aging [J].

Rodriguez, Miriam ;

Snoek, L. Basten ;

De Bono, Mario ;

Kammenga, Jan E. .

TRENDS IN GENETICS, 2013, 29 (06) :367-374

[110] Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides [J].

Ross, Sarah Jane Mackenzie ;

Brewin, Chris Ray ;

Curran, Helen Valerie ;

Furlong, Clement Eugene ;

Abraham-Smith, Kelly Michelle ;

Harrison, Virginia .

NEUROTOXICOLOGY AND TERATOLOGY, 2010, 32 (04) :452-459

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