Self-assembly based aerosolized hyaluronic acid (HA) loaded niosomes for lung delivery: An in-vitro and in-vivo evaluation

被引：10
|
作者：
Kulkarni, Pratik [1 ]
Rawtani, Deepak [1 ]
Rajpurohit, Sejal [1 ]
Vasvani, Shyam [1 ]
Barot, Tejas [1 ]
机构：
[1] Natl Forens Sci Univ, Nr DFS Head Quarters, Sect 9, Gandhinagar 382007, Gujarat, India
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2022年 / 75卷
关键词：
Hyaluronic acid; Niosomes; Controlled release; Aerosol delivery; Lung delivery; Asthma; BOX-BEHNKEN DESIGN; RELEASE; BIOAVAILABILITY; ENCAPSULATION; OPTIMIZATION; FORMULATION; DRUGS; METHOTREXATE; RIVASTIGMINE; INFLAMMATION;
D O I：
10.1016/j.jddst.2022.103627
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hyaluronic acid, a biological macromolecule, was utilized as a drug for loading into niosomes. The ethanol injection method was used to formulate the niosomes using Cholesterol as the lipid and Span 80 as the non-ionic surfactant. HA-loaded niosomes showed a particle size of 177.6 nm and a % Entrapment Efficiency (%EE) of >95%. Drug release studies from the HA-loaded niosomes showed a controlled release profile for up to 4 days. Robust stability of the HA-loaded niosomes at both R.T (25-30 degrees C) and 4-8 degrees C was obtained. DPPH (2,2diphenyl-1-picrylhydrazyl) antioxidant assay exhibited a greater enzyme inhibition than the free HA solution. Invivo pharmacokinetic drug estimation parameters revealed a greater HA plasma concentration than free HA solution through the aerosol route. Moreover, organ biodistribution studies showed a greater localization of HA in lungs than in other organs.
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页数：11
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