Alzheimer's Disease Diagnosis and Severity Level Detection Based on Electroencephalography Modulation Spectral "Patch" Features

Over the last two decades, electroencephalography (EEG) has emerged as a reliable tool for the diagnosis of cortical disorders such as Alzheimer's disease (AD). Typically, resting-state EEG (rsEEG) signals have been used, and traditional frequency bands (delta, theta, alpha, beta and gamma) have been explored. Recent studies, however, have suggested that non-conventional bands may lead to improved diagnostic performance. In this work, we propose a new type of features derived from the 2-dimensional modulation spectral domain representation of the rsEEG signal in order to characterize the neuromodulatory deficit emergent with AD. The proposed features are computed as the power in specific "patches" or regions of interest in the power modulation spectrogram, which are shown to be highly discriminant of AD severity levels. The proposed features were compared with traditional features used in the rsEEG AD monitoring literature. Results showed the proposed features not only achieving improved performance at discriminating between healthy normal elderly controls (Nold) and AD patients with varying severity levels, but also at monitoring severity levels (i.e., mild AD versus moderate AD). Moreover, the proposed features were shown to outperform traditional rsEEG features. Finally, we validated the biological origin of the proposed features by using source localization and comparing the obtained results with ones reported in the AD literature.