ChimeraScan: a tool for identifying chimeric transcription in sequencing data

被引：206

作者：

Iyer, Matthew K. ^{[1
,2
]}

Chinnaiyan, Arul M. ^{[1
,2
,3
,4
,5
]}

Maher, Christopher A. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Sch Med, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Computat Med & Biol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Sch Med, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA

来源：

BIOINFORMATICS | 2011年 / 27卷 / 20期

基金：

美国国家卫生研究院;

关键词：

CANCER; FUSION;

D O I：

10.1093/bioinformatics/btr467

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Next generation sequencing (NGS) technologies have enabled de novo gene fusion discovery that could reveal candidates with therapeutic significance in cancer. Here we present an open-source software package, ChimeraScan, for the discovery of chimeric transcription between two independent transcripts in high-throughput transcriptome sequencing data.

引用

页码：2903 / 2904

页数：2

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