Updates of cancer hallmarks in patients with inborn errors of immunity

被引：5

作者：

Wang, Yating ^{[1
]}

Abolhassani, Hassan ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Biosci & Nutr, Div Clin Immunol, Stockholm, Sweden

[2] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Pediat Ctr Excellence, Childrens Med Ctr, Tehran, Iran

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2022年 / 22卷 / 06期

关键词：

epigenetic; hallmarks of cancer; inborn errors of immunity; microbiome; primary immunodeficiency; senescence; CELL DIFFERENTIATION; METABOLITE BUTYRATE; DNA METHYLATION; CRITICAL ROLES; DEFICIENCY; IMMUNODEFICIENCY; RECEPTOR; INFLAMMATION; ACTIVATION; SENESCENCE;

D O I：

10.1097/ACI.0000000000000863

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Purpose of review The development of cancer in patients with genetically determined inborn errors of immunity (IEI) is much higher than in the general population. The hallmarks of cancer are a conceptualization tool that can refine the complexities of cancer development and pathophysiology. Each genetic defect may impose a different pathological tumor predisposition, which needs to be identified and linked with known hallmarks of cancer. Recent findings Four new hallmarks of cancer have been suggested, recently, including unlocking phenotypic plasticity, senescent cells, nonmutational epigenetic reprogramming, and polymorphic microbiomes. Moreover, more than 50 new IEI genes have been discovered during the last 2 years from which 15 monogenic defects perturb tumor immune surveillance in patients. This review provides a more comprehensive and updated overview of all 14 cancer hallmarks in IEI patients and covers aspects of cancer predisposition in novel genes in the ever-increasing field of IEI.

引用

页码：352 / 363

页数：12

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