Bleaching earth clay (pH 12.5)/PEG-400: an efficient recyclable catalytic system for synthesis of 5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives

被引：3

作者：

Mogle, Pratima P. ^{[1
]}

Kamble, Rahul D. ^{[1
]}

Hese, Shrikant V. ^{[1
]}

Dawane, Bhaskar S. ^{[1
]}

机构：

[1] Swami Ramanand Teerth Marathwada Univ, Sch Chem Sci, Nanded, MS, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 10期

关键词：

Bleaching earth clay (pH 12.5); PEG-400; Tetrahydroquinoline-3-carbonitrile; POLY(ETHYLENE GLYCOL); POTENT INHIBITORS; RAPID SYNTHESIS; PH; 12.5; SOLVENT; ANALOGS; SERIES; PEG;

D O I：

10.1007/s11164-014-1842-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A green, efficient, and simple method for synthesis of 5,6,7,8-tetrahydroquinoline-3-carbonitrile derivatives via one-pot three-component condensation of 2,6-bis(substituted benzylidene)cyclohexanone, arylamines/substituted 2-aminothiazoles, and malononitrile in the presence of bleaching earth clay pH 12.5 (basic catalyst) as a recyclable and green catalyst in PEG-400 is described. Catalyst recyclability, good to excellent product yield, shorter reaction time, and avoidance of hazardous reagents are the main advantages of this methodology.

引用

页码：7541 / 7551

页数：11

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