Design and Rationale of the Biomarker Center of the Household Air Pollution Intervention Network (HAPIN) Trial

被引:26
作者
Barr, Dana Boyd [1 ]
Puttaswamy, Naveen [2 ]
Jaacks, Lindsay M. [3 ]
Steenland, Kyle [1 ]
Rajkumar, Sarah [2 ]
Gupton, Savannah [1 ]
Ryan, P. Barry [1 ]
Balakrishnan, Kalpana [2 ]
Peel, Jennifer L. [4 ]
Checkley, William [5 ,6 ]
Clasen, Thomas [1 ]
Clark, Maggie L. [4 ]
机构
[1] Emory Univ, Rollins Sch Publ Hlth, Gangarosa Dept Environm Hlth, Atlanta, GA 30322 USA
[2] Sri Ramachandra Inst Higher Educ & Res Deemed Uni, ICMR Ctr Adv Res Air Qual Climate & Hlth, Dept Environm Hlth Engn, Chennai, Tamil Nadu, India
[3] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA
[4] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA
[5] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care, Baltimore, MD USA
[6] Johns Hopkins Univ, Sch Med, Ctr Global Noncommunicable Dis Res & Training, Baltimore, MD USA
基金
比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;
关键词
CHROMATOGRAPHY-MASS-SPECTROMETRY; METABOLOME-WIDE ASSOCIATION; CELL SECRETORY PROTEIN; ENVIRONMENTAL CHEMICALS; OCCUPATIONAL-EXPOSURE; MEDIATION ANALYSIS; CROSS-VALIDATION; OVARIAN-CANCER; BLOOD-LIPIDS; LUNG-CANCER;
D O I
10.1289/EHP5751
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
BACKGROUND: Biomarkers of exposure, susceptibility, and effect are fundamental for understanding environmental exposures, mechanistic pathways of effect, and monitoring early adverse outcomes. To date, no study has comprehensively evaluated a large suite and variety of biomarkers in household air pollution (HAP) studies in concert with exposure and outcome data. The Household Air Pollution Intervention Network (HAPIN) trial is a liquified petroleum gas (LPG) fuel/stove randomized intervention trial enrolling 800 pregnant women in each of four countries (i.e., Peru, Guatemala, Rwanda, and India). Their offspring will be followed from birth through 12 months of age to evaluate the role of pie- and postnatal exposure to HAP from biomass burning cookstoves in the control arm and LPG stoves in the intervention arm on growth and respiratory outcomes. In addition, up to 200 older adult women per site are being recruited in the same households to evaluate indicators of cardiopulmonary, metabolic, and cancer outcomes. OBJECTIVES: Here we describe the rationale and ultimate design of a comprehensive biomarker plan to enable us to explore more fully how exposure is related to disease outcome. METHODS: HAPIN enrollment and data collection began in May 2018 and will continue through August 2021. As a part of data collection, dried blood spot (DBS) and urine samples are being collected three times during pregnancy in pregnant women and older adult women. DBS are collected at birth for the child. DBS and urine samples are being collected from the older adult women and children three times throughout the child's first year of life. Exposure biomarkers that will be longitudinally measured in all participants include urinary hydroxy-polycyclic aromatic hydrocarbons, volatile organic chemical metabolites, metals/metalloids, levoglucosan, and cotinine. Biomarkers of effect, including inflammation, endothelial and oxidative stress biomarkers, lung cancer markers, and other clinically relevant measures will be analyzed in urine, DBS, or blood products from the older adult women. Similarly, genomic/epigenetic markers, microbiome, and metabolomics will be measured in older adult women samples. DISCUSSION: Our study design will yield a wealth of biomarker data to evaluate, in great detail, the link between exposures and health outcomes. In addition, our design is comprehensive and innovative by including cutting-edge measures such as metabolomics and epigenetics.
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页数:10
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