HIV Type 1 Subtypes Based on the pol Gene and Drug Resistance Mutations Among Antiretroviral-Naive Patients from Guangxi, Southern China

被引：1

作者：

Su, Qijian ^{[1
]}

Liang, Hao ^{[2
]}

Cen, Ping ^{[3
]}

Bi, Zhiyou ^{[3
]}

Zhou, Ping ^{[4
]}

机构：

[1] Guangxi Tradit Chinese Med Univ, Affiliated Ruikang Hosp, Ctr AIDS Res, Nanning 530011, Guangxi, Peoples R China

[2] Guangxi Med Univ, Coll Publ Hlth, Nanning, Peoples R China

[3] Nanning Ctr Dis Control & Prevent, Dept AIDS Control & Prevent, Nanning, Peoples R China

[4] Liuzhou Ctr Dis Control & Prevent, Dept TB Control & Prevent, Liuzhou, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 07期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; RECOMMENDATIONS; SEQUENCES;

D O I：

10.1089/aid.2011.0246

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the distribution of HIV-1 subtypes and the prevalence of HIV-1 drug resistance among HIV-infected antiretroviral-naive patients in Guangxi, southern China. A total of 144 subjects from Liuzhou or Nanning, two cities having the most HIV-infected cases in Guangxi, were enrolled. HIV-1 pol fragments were amplified and sequenced from plasma of all patients. In all, 124 sequences were obtained, with 67 from Liuzhou and 57 from Nanning. All sequences were subtyped by phylogenetic analysis and analyzed for antiretroviral resistance using the HIVdb program. Our data showed that the sequences from Liuzhou were subtyped as CRF01_AE (77.6%), CRF07_BC(20.9%), and BC (1.5%), respectively, and the sequences from Nanning as CRF01_AE (78.9%), CRF08_BC (15.8%), B (3.5%), and C (1.8%), respectively. Of the sequences 11.9% from Liuzhou and 28.1% from Nanning harbored drug resistance-associated mutations, but there were only two sequences with mutations associated with significantly reduced phenotypic susceptibility to antiretroviral drugs.

引用

页码：725 / 728

页数：4