Adaptation of mRNA structure to control protein folding

被引：23
|
作者：
Faure, Guilhem [1 ]
Ogurtsov, Aleksey Y. [1 ]
Shabalina, Svetlana A. [1 ]
Koonin, Eugene V. [1 ]
机构：
[1] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA
来源：
RNA BIOLOGY | 2017年 / 14卷 / 12期
关键词：
mRNA structure; protein structure; cotranslational protein folding; translation pausing; mRNA evolution; AMINO-ACID SUBSTITUTION; SECONDARY STRUCTURE; TRANSLATION ELONGATION; GENE-EXPRESSION; CODING REGIONS; SEQUENCE; EVOLUTION; COMPLEXITY; SELECTION; SILENCE;
D O I：
10.1080/15476286.2017.1349047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Comparison of mRNA and protein structures shows that highly structured mRNAs typically encode compact protein domains suggesting that mRNA structure controls protein folding. This function is apparently performed by distinct structural elements in the mRNA, which implies 'fine tuning' of mRNA structure under selection for optimal protein folding. We find that, during evolution, changes in the mRNA folding energy follow amino acid replacements, reinforcing the notion of an intimate connection between the structures of a mRNA and the protein it encodes, and the double encoding of protein sequence and folding in the mRNA.
引用
收藏
页码：1649 / 1654
页数：6
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