Familial Clustering of Breast and Prostate Cancer and Risk of Postmenopausal Breast Cancer in the Women's Health Initiative Study

被引:27
作者
Beebe-Dimmer, Jennifer L. [1 ,2 ]
Yee, Cecilia [1 ,2 ]
Cote, Michele L. [1 ,2 ]
Petrucelli, Nancie [1 ,2 ]
Palmer, Nynikka [3 ]
Bock, Cathryn [1 ,2 ]
Lane, Dorothy [4 ]
Agalliu, Ilir [5 ,6 ,7 ]
Stefanick, Marcia L. [8 ,9 ]
Simon, Michael S. [1 ,2 ]
机构
[1] Karmanos Canc Inst, Detroit, MI 48201 USA
[2] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[4] SUNY Stony Brook, Dept Community & Behav Hlth, Stony Brook, NY 11794 USA
[5] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA
[6] Albert Einstein Coll Med, Dept Populat Hlth, Bronx, NY 10467 USA
[7] Albert Einstein Coll Med, Dept Urol, Bronx, NY 10467 USA
[8] Stanford Univ, Dept Med, Stanford, CA 94305 USA
[9] Stanford Univ, Dept Obstet & Gynecol, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
African American; aggregation; epidemiology; family history; genetics; GERMLINE MUTATIONS; HISTORY; BRCA2; MEN; RELATIVES; WHITE; GENE;
D O I
10.1002/cncr.29075
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUNDEvidence suggests that the risk of breast and prostate cancer is increased among those with a family history of the same disease and particularly among first-degree relatives. However, less is known about the relationship between breast and prostate cancer within families and particularly among minority populations. METHODSAnalyses of participants in the Women's Health Initiative observational cohort who were free of breast cancer at the time of their baseline examination were conducted. Subjects were followed for breast cancer through August 31, 2009. A Cox proportional hazards regression modeling approach was used to estimate the risk of breast cancer associated with a family history of prostate cancer, breast cancer, and both among first-degree relatives. RESULTSThere were 78,171 eligible participants, and 3506 breast cancer cases were diagnosed during the study period. A family history of prostate cancer was associated with a modest increase in breast cancer risk after adjustments for confounders (adjusted hazard ratio [aHR], 1.14; 95% confidence interval [CI], 1.02-1.26). In a separate analysis examining the joint impact of both cancers, a family history of both breast and prostate cancer was associated with a 78% increase in breast cancer risk (aHR, 1.78; 95% CI, 1.45-2.19). Risk estimates associated with a family history of both breast and prostate cancer were higher among African American women (aHR, 2.34; 95% CI, 1.09-5.02) versus white women (aHR, 1.66; 95% CI, 1.33-2.08). CONCLUSIONSThese findings suggest that prostate cancer diagnosed among first-degree family members increases a woman's risk of developing breast cancer. Future studies are needed to determine the relative contributions of genes and a shared environment to the risk for both cancers. Cancer 2015;121:1265-1272. (c) 2014 American Cancer Society. A family history of prostate cancer among first-degree relatives increases one's risk for breast cancer diagnosed after the age of 50 years. Information on one's family cancer history is critical for risk assessment and may influence decisions about screening for early detection.
引用
收藏
页码:1265 / 1272
页数:8
相关论文
共 44 条
[1]   Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer [J].
Agalliu, I. ;
Karlins, E. ;
Kwon, E. M. ;
Iwasaki, L. M. ;
Diamond, A. ;
Ostrander, E. A. ;
Stanford, J. L. .
BRITISH JOURNAL OF CANCER, 2007, 97 (06) :826-831
[2]   Associations of High-Grade Prostate Cancer with BRCA1 and BRCA2 Founder Mutations [J].
Agalliu, Ilir ;
Gern, Robert ;
Leanza, Suzanne ;
Burk, Robert D. .
CLINICAL CANCER RESEARCH, 2009, 15 (03) :1112-1120
[3]  
Anderson G, 1998, CONTROL CLIN TRIALS, V19, P61
[4]  
[Anonymous], ANN ONCOL
[5]   Segregation analysis of 389 Icelandic pedigrees with breast and prostate cancer [J].
Baffoe-Bonnie, AB ;
Kiemeney, LALM ;
Beaty, TH ;
Bailey-Wilson, JE ;
Schnell, AH ;
Sigvaldason, H ;
Olafsdóttir, G ;
Tryggvadóttir, L ;
Tulinius, H .
GENETIC EPIDEMIOLOGY, 2002, 23 (04) :349-363
[6]   Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study [J].
Bancroft, Elizabeth K. ;
Page, Elizabeth C. ;
Castro, Elena ;
Lilja, Hans ;
Vickers, Andrew ;
Sjoberg, Daniel ;
Assel, Melissa ;
Foster, Christopher S. ;
Mitchell, Gillian ;
Drew, Kate ;
Maehle, Lovise ;
Axcrona, Karol ;
Evans, D. Gareth ;
Bulman, Barbara ;
Eccles, Diana ;
McBride, Donna ;
van Asperen, Christi ;
Vasen, Hans ;
Kiemeney, Lambertus A. ;
Ringelberg, Janneke ;
Cybulski, Cezary ;
Wokolorczyk, Dominika ;
Selkirk, Christina ;
Hulick, Peter J. ;
Bojesen, Anders ;
Skytte, Anne-Bine ;
Lam, Jimmy ;
Taylor, Louise ;
Oldenburg, Rogier ;
Cremers, Ruben ;
Verhaegh, Gerald ;
van Zelst-Stams, Wendy A. ;
Oosterwijk, Jan C. ;
Blanco, Ignacio ;
Salinas, Monica ;
Cook, Jackie ;
Rosario, Derek J. ;
Buys, Saundra ;
Conner, Tom ;
Ausems, Margreet G. ;
Ong, Kai-ren ;
Hoffman, Jonathan ;
Domchek, Susan ;
Powers, Jacquelyn ;
Teixeira, Manuel R. ;
Maia, Sofia ;
Foulkes, William D. ;
Taherian, Nassim ;
Ruijs, Marielle ;
Helderman-van den Enden, Apollonia T. .
EUROPEAN UROLOGY, 2014, 66 (03) :489-499
[7]   Association between family history of prostate and breast cancer among African-American men with prostate cancer [J].
Beebe-Dimmer, Jennifer L. ;
Drake, Elizabeth A. ;
Dunn, Rodney L. ;
Bock, Cathryn H. ;
Montie, James E. ;
Cooney, Kathleen A. .
UROLOGY, 2006, 68 (05) :1072-1076
[8]   Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease [J].
Beral, V ;
Bull, D ;
Doll, R ;
Peto, R ;
Reeves, G .
LANCET, 2001, 358 (9291) :1389-1399
[9]   Risk for incident and fatal prostate cancer in men with a family history of any incident and fatal cancer [J].
Brandt, A. ;
Sundquist, J. ;
Hemminki, K. .
ANNALS OF ONCOLOGY, 2012, 23 (01) :251-U98
[10]   Relative risk of prostate cancer for men with affected relatives: Systematic review and meta-analysis [J].
Bruner, DW ;
Moore, D ;
Parlanti, A ;
Dorgan, J ;
Engstrom, P .
INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (05) :797-803