Stable IL-10: A New Therapeutic that Promotes Tumor Immunity

被引：31
|
作者：
Teng, Michele W. L. [1 ,2 ]
Darcy, Phillip K. [1 ,2 ]
Smyth, Mark J. [1 ,2 ]
机构：
[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3002, Australia
[2] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia
来源：
CANCER CELL | 2011年 / 20卷 / 06期
关键词：
INTERLEUKIN-10; INFLAMMATION; METASTASIS; CYTOKINES; ANTITUMOR; CANCER; GAMMA; IL-23;
D O I：
10.1016/j.ccr.2011.11.020
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Mumm et al. demonstrate that pegylated IL-10 increases CD8(+) T cell numbers, IFN-gamma secretion, and cytotoxicity in established tumors, enhancing antigen presentation machinery and suppressing tumor growth. This approach may enhance T cell immune responses in cancers with reduced T cell infiltration.
引用
收藏
页码：691 / 693
页数：3
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