Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels-Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms

被引：17

作者：

Lorion, Magali ^{[1
]}

Guillaumet, Gerald ^{[1
]}

Briere, Jean-Francois ^{[2
,3
,4
,5
]}

Suzenet, Franck ^{[1
]}

机构：

[1] Univ Orleans, CNRS, ICOA, UMR 7311, F-45067 Orleans, France

[2] Normandie Univ, COBRA, UMR 6014, F-76821 Mont St Aignan, France

[3] FR 3038, F-76821 Mont St Aignan, France

[4] Univ Rouen, INSA Rouen, F-76821 Mont St Aignan, France

[5] CNRS, IRCOF, F-76821 Mont St Aignan, France

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 12期

关键词：

HETEROCYCLIC AZADIENES; EFFICIENT ROUTE; 1,2,4-TRIAZINES; PYRIDINE; 2,2'-BIPYRIDINE; CONVENIENT; LIGANDS; KETONES; ANALOGS;

D O I：

10.1021/acs.orglett.5b01487

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An original one-pot Michael addition-ihDA/rDA sequence was achieved from 3-vinyl-1,2,4-triazine platforms used as unprecedented Michael acceptors. This sequence provides a novel access to functionalized [2,3]-fused pyridine derivatives via a unique enamine promoted intramolecular ihDA reaction of 1,2,4-triazine intermediates.

引用

页码：3154 / 3157

页数：4

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