Synthesis, crystal structure and anaerobic DNA photocleavage of ruthenium complexes [Ru(tpy)(dpoq)Cl]+ and [Ru(tpy)(dpoq)CH3CN]2+

被引：9
|
作者：
Yu, Hui-juan [1 ,2 ]
Huang, Shu-mei [2 ]
Chao, Hui [2 ]
Ji, Liang-nian [2 ]
机构：
[1] Guangdong Univ Technol, Fac Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, MOE Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2015年 / 149卷
关键词：
Ruthenium complex; Photodynamic therapy; Anaerobic photocleavage; RU(II) POLYPYRIDINE COMPLEXES; PHOTODYNAMIC THERAPY; METAL-COMPLEXES; DEOXYRIBONUCLEIC-ACID; SEQUENCE SELECTIVITY; ELECTRON-TRANSFER; ETHIDIUM BROMIDE; NUCLEIC ACIDS; BINDING; OXIDATION;
D O I：
10.1016/j.jinorgbio.2015.02.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new Ru(II) complexes [Ru(tpy)(dpoq)Cl](+) 1 and [Ru(tpy)(dpoq)CH3CN](2+) 2 (tpy = 2,2':6',2"-terpyridine; dpoq = dipyrido[1,2,5]oxadiazolo[3,4-b]quinoxaline) have been synthesized and characterized by elemental analysis, H-1 NMR, electrospray ionization mass spectra (ESI-MS) and X-ray crystallographic study. The experimental results of spectra titration, thermal denaturation and viscosity measurements suggest that the two complexes intercalatively bind to DNA. When irradiated under light, the two complexes could efficiently photocleave DNA both under aerobic and anaerobic condition. The mechanism studies reveal that the photocleavage reaction functions through both oxygen-independent (photoinduced electron transfer, type III reaction) and oxygen-dependent (singlet oxygen generation, type II reaction) pathways and the oxygen-independent pathway is the major process. These complexes will be more promising photodynamic therapy (PDT) candidates used for treating hypoxic tumors. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：80 / 87
页数：8
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