Rational design of Au nanorods assemblies for highly sensitive and selective SERS detection of prostate specific antigen

被引：22

作者：

Yang, An-qi ^{[1
]}

Wang, Dong ^{[1
,2
]}

Wang, Xiang ^{[2
]}

Han, Yu ^{[1
]}

Ke, Xue-bin ^{[1
]}

Wang, Hong-jun ^{[3
]}

Zhou, Xi ^{[1
]}

Ren, Lei ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Mat, Dept Biomat, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[3] Stevens Inst Technol, Dept Chem Chem Biol & Biomed Engn, Hoboken, NJ 07030 USA

来源：

RSC ADVANCES | 2015年 / 5卷 / 48期

关键词：

GOLD NANORODS; PSA DETECTION; NANOPARTICLES; ENHANCEMENT; BIOSENSOR; PATHOGENS; SYSTEM; PROBES;

D O I：

10.1039/c5ra01322d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile approach for highly sensitive surface-enhanced Raman scattering (SERS) detection of prostate specific antigen (PSA) has been developed based on immune recognition assisted fabrication of gold nanorods (AuNRs) assemblies. Compared with the typical enzyme-linked immunosorbent assay, this SERS immunoassay strategy showed an obviously enhanced sensitivity. The SERS immunoassay for PSA detection has also been successfully applied in diluted human serum samples, showing the promising potential for early diagnosis of diseases in clinical application.

引用

页码：38354 / 38360

页数：7

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