Genetic and environmental factors underlying keratinocyte carcinoma risk

被引：22
作者：
Choque, Helene [1 ]
Ashrafzad, Sepideh [2 ,3 ]
Kim, Yuhree [2 ,3 ]
Asgari, Maryam M. [2 ,3 ]
Jorgenson, Eric [1 ]
机构：
[1] Kaiser Permanente Northern Calif, Div Res, 2000 Broadway, Oakland, CA 94612 USA
[2] Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA
[3] Harvard Med Sch, Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA 02115 USA
来源：
JCI INSIGHT | 2020年 / 5卷 / 10期
关键词：
CUTANEOUS SQUAMOUS-CELL; NONMELANOMA SKIN-CANCER; GENOME-WIDE ASSOCIATION; BASAL-CELL; TRANSPLANT RECIPIENTS; VITAMIN-D; ORAL-CONTRACEPTIVES; IONIZING-RADIATION; ULTRAVIOLET-RADIATION; VISMODEGIB TREATMENT;
D O I：
10.1172/jci.insight.134783
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recent large-scale GWAS and large epidemiologic studies have accelerated the discovery of genes and environmental factors that contribute to the risk of keratinocyte carcinoma (KC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This Review summarizes the genomic regions associated with SCC and BCC risk, examines the genetic overlap between SCC and BCC, and discusses biological pathways involved in SCC and BCC development. Next, we review environmental factors that are associated with KC risk, including those that are shared between SCC and BCC as well as others that associated with only one type of KC. We conclude with a critical appraisal of current research and potential directions for future research.
引用
收藏
页数：14
相关论文
共 121 条
[41]   Emergence of a squamous cell carcinoma phenotype following treatment of metastatic basal cell carcinoma with vismodegib [J].
Iarrobino, Amy ;
Messina, Jane L. ;
Kudchadkar, Ragini ;
Sondak, Vernon K. .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2013, 69 (01) :E33-E34
[42]   Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma [J].
Ioannidis, Nilah M. ;
Wang, Wei ;
Furlotte, Nicholas A. ;
Hinds, David A. ;
Bustamante, Carlos D. ;
Jorgenson, Eric ;
Asgari, Maryam M. ;
Whittemore, Alice S. .
NATURE COMMUNICATIONS, 2018, 9
[43]   Familial skin cancer syndromes Increased risk of nonmelanotic skin cancers and extracutaneous tumors [J].
Jaju, Prajakta D. ;
Ransohoff, Katherine J. ;
Tang, Jean Y. ;
Sarin, Kavita Y. .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2016, 74 (03) :437-451
[44]  
Jellouli-Elloumi A, 2003, ANN DERMATOL VENER, V130, P413
[45]   Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens [J].
Jensen, P ;
Hansen, S ;
Moller, B ;
Leivestad, T ;
Pfeffer, P ;
Geiran, O ;
Fauchald, P ;
Simonsen, S .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 40 (02) :177-186
[46]   Risk of basal cell and squamous cell skin cancers after ionizing radiation therapy [J].
Karagas, MR ;
McDonald, JA ;
Greenberg, ER ;
Stukel, TA ;
Weiss, JE ;
Baron, JA ;
Stevens, M .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1996, 88 (24) :1848-1853
[47]   Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States [J].
Kim, Jongwoo ;
Park, Min Kyung ;
Li, Wen-Qing ;
Qureshi, Abrar A. ;
Cho, Eunyoung .
JAMA DERMATOLOGY, 2019, 155 (11) :1260-1268
[48]   Risk of skin cancer and other malignancies in kidney, liver, heart and lung transplant recipients 1970 to 2008-A Swedish population-based study [J].
Krynitz, Britta ;
Edgren, Gustaf ;
Lindelof, Bernt ;
Baecklund, Eva ;
Brattstrom, Christina ;
Wilczek, Henryk ;
Smedby, Karin E. .
INTERNATIONAL JOURNAL OF CANCER, 2013, 132 (06) :1429-1438
[49]   Alcohol consumption and risk of melanoma and non-melanoma skin cancer in the Women's Health Initiative [J].
Kubo, Jessica T. ;
Henderson, Michael T. ;
Desai, Manisha ;
Wactawski-Wende, Jean ;
Stefanick, Marcia L. ;
Tang, Jean Y. .
CANCER CAUSES & CONTROL, 2014, 25 (01) :1-10
[50]   Sex hormones and the risk of keratinocyte cancers among women in the United States: A population-based case-control study [J].
Kuklinski, Lawrence F. ;
Zens, Michael S. ;
Perry, Ann E. ;
Gossai, Anala ;
Nelson, Heather H. ;
Karagas, Margaret R. .
INTERNATIONAL JOURNAL OF CANCER, 2016, 139 (02) :300-309
12345678910