Genetic and environmental factors underlying keratinocyte carcinoma risk

被引：22

作者：

Choque, Helene ^{[1
]}

Ashrafzad, Sepideh ^{[2
,3
]}

Kim, Yuhree ^{[2
,3
]}

Asgari, Maryam M. ^{[2
,3
]}

Jorgenson, Eric ^{[1
]}

机构：

[1] Kaiser Permanente Northern Calif, Div Res, 2000 Broadway, Oakland, CA 94612 USA

[2] Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA

[3] Harvard Med Sch, Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA 02115 USA

来源：

JCI INSIGHT | 2020年 / 5卷 / 10期

关键词：

CUTANEOUS SQUAMOUS-CELL; NONMELANOMA SKIN-CANCER; GENOME-WIDE ASSOCIATION; BASAL-CELL; TRANSPLANT RECIPIENTS; VITAMIN-D; ORAL-CONTRACEPTIVES; IONIZING-RADIATION; ULTRAVIOLET-RADIATION; VISMODEGIB TREATMENT;

D O I：

10.1172/jci.insight.134783

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recent large-scale GWAS and large epidemiologic studies have accelerated the discovery of genes and environmental factors that contribute to the risk of keratinocyte carcinoma (KC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This Review summarizes the genomic regions associated with SCC and BCC risk, examines the genetic overlap between SCC and BCC, and discusses biological pathways involved in SCC and BCC development. Next, we review environmental factors that are associated with KC risk, including those that are shared between SCC and BCC as well as others that associated with only one type of KC. We conclude with a critical appraisal of current research and potential directions for future research.

引用

页数：14

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