MALIGNANCIES IN β-THALASSEMIA PATIENTS: FIRST DESCRIPTION OF TWO CASES OF THYROID CANCER AND REVIEW OF THE LITERATURE

被引：20

作者：

Poggi, Maurizio ^{[1
]}

Sorrentino, Francesco ^{[2
]}

Pascucci, Chiara ^{[1
]}

Monti, Salvatore ^{[1
]}

Lauri, Chiara ^{[1
]}

Bisogni, Valeria ^{[1
]}

Toscano, Vincenzo ^{[1
]}

Cianciulli, Paolo ^{[2
]}

机构：

[1] Univ Roma La Sapienza, Fac Med 2, Chair Endocrinol, Rome, Italy

[2] S Eugenio Hosp, Thalassemia Unit, Rome, Italy

来源：

HEMOGLOBIN | 2011年 / 35卷 / 04期

关键词：

Thalassemia; Thyroid Cancer; Iron; Endocrine neoplasia; IRON; DISEASE; COMPLICATIONS; MULTICENTER; INTERMEDIA;

D O I：

10.3109/03630269.2011.588355

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-Thalassemias are a group of hereditary blood disorders characterized by abnormalities in the synthesis of the beta hemoglobin (Hb) chains. This disease causes excessive storage of iron in all organs and endocrine glands. Treatment of beta-thalassemia major (beta-TM) consists of regular blood transfusions, iron chelation and management of secondary complications of iron overload. Endocrine abnormalities are frequently observed. In the last 25 years, the clinical picture of the disease has changed progressively thanks to improvement of treatments. Today, the majority of thalassemic patients reach adult age. The better prognosis and the longer lifespan of affected patients could be responsible for the susceptibility to other concomitant diseases which can manifest during their life. In this context, the possibility and recent literature reports about some cases of malignancy in thalassemic patients open new scenarios for oncoming years. We describe first reports of endocrine malignancies in thalassemic patients.

引用

页码：439 / 446

页数：8

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