Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years

被引：61

作者：

Kidd, Timothy J. ^{[17
]}

Ramsay, Kay A. ^{[17
]}

Vidmar, Suzanna ^{[7
,8
,18
,19
]}

Carlin, John B. ^{[7
,8
,18
,19
]}

Bell, Scott C. ^{[17
,20
]}

Wainwright, Claire E. ^{[1
,2
,17
,21
]}

Grimwood, Keith ^{[1
,3
,17
,22
,23
]}

Wainwright, Claire E. ^{[1
,2
,17
,21
]}

Grimwood, Keith ^{[1
,3
,17
,22
,23
]}

Francis, Paul W. ^{[4
]}

Dakin, Carolyn ^{[5
]}

Cheney, Joyce ^{[1
,2
]}

George, Narelle ^{[6
]}

Carlin, John B. ^{[7
,8
,18
,19
]}

Robertson, Colin F. ^{[9
]}

Vidmar, Suzanna ^{[7
,8
,18
,19
]}

Moodie, Marj ^{[10
]}

Carzino, Rosemary ^{[9
]}

Carter, Robert ^{[10
]}

Armstrong, David S. ^{[11
]}

Cooper, Peter J. ^{[12
]}

Mckay, Karen ^{[12
]}

Martin, A. James ^{[13
]}

Whitehead, Bruce

Hunter, John ^{[14
]}

By-Rnes, Catherine A. ^{[15
]}

Tiddens, Harm A. ^{[16
]}

Graniel, Karla

Gerbrands, Krista

Mott, Lauren

机构：

[1] Queensland Childrens Med Res Inst, Brisbane, Qld, Australia

[2] Univ Queensland, Brisbane, Qld, Australia

[3] Griffith Univ, Brisbane, Qld 4111, Australia

[4] Royal Childrens Hosp, Brisbane, Qld, Australia

[5] Univ Queensland, Mater Childrens Hosp, Brisbane, Qld 4101, Australia

[6] Pathol Queensland, Brisbane, Qld, Australia

[7] Murdoch Childrens Res Inst, Melbourne, Australia

[8] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[9] Royal Childrens Hosp, Melbourne, Vic, Australia

[10] Deakin Univ, Melbourne, Vic, Australia

[11] Monash Med Ctr, Melbourne, Vic, Australia

[12] Childrens Hosp Westmead, Sydney, NSW, Australia

[13] Womens & Childrens Hosp, Adelaide, SA, Australia

[14] Childrens Hosp, Newcastle, NSW, Australia

[15] Starship Childrens Hosp, Auckland, New Zealand

[16] Erasmus MC, Rotterdam, Netherlands

[17] Univ Queensland, Royal Childrens Hosp, Queensland Childrens Med Res Inst, Herston, Qld 4029, Australia

[18] Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Parkville, Vic 3052, Australia

[19] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

[20] Prince Charles Hosp, Dept Thorac Med, Cherinside, Qld 4032, Australia

[21] Royal Childrens Hosp, Queensland Childrens Resp Ctr, Herston, Qld 4029, Australia

[22] Griffith Univ, Griffith Hlth Inst, Southport, Qld 4222, Australia

[23] Gold Coast Univ Hosp, Southport, Qld 4222, Australia

来源：

JOURNAL OF CYSTIC FIBROSIS | 2015年 / 14卷 / 03期

基金：

英国医学研究理事会;

关键词：

Pseudomonas aeruginosa; Cystic fibrosis; Infection; Genotyping; Eradication; LAVAGE-DIRECTED THERAPY; CHRONIC LUNG INFECTION; YOUNG-CHILDREN; BRONCHOALVEOLAR LAVAGE; OROPHARYNGEAL CULTURES; ERADICATION THERAPY; DIAGNOSTIC-TOOL; STRAINS; INFANTS; COLONIZATION;

D O I：

10.1016/j.jcf.2014.12.007

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: We describe Pseudomonas aeruginosa acquisitions in children with cystic fibrosis (CF) aged <= 5-years, eradication treatment efficacy, and genotypic relationships between upper and lower airway isolates and strains from non-CF sources. Methods: Of 168 CF children aged <= 5-years in a bronchoalveolar lavage (BAL)-directed therapy trial, 155 had detailed microbiological results. Overall, 201/271 (74%) P. aeruginosa isolates from BAL and oropharyngeal cultures were available for genotyping, including those collected before and after eradication therapy. Results: Eighty-two (53%) subjects acquired P. aeruginosa, of which most were unique strains. Initial eradication success rate was 90%, but 36 (44%) reacquired P. aeruginosa, with genotypic substitutions more common in BAL (12/14) than oropharyngeal (3/11) cultures. Moreover, oropharyngeal cultures did not predict BAL genotypes reliably. Conclusions: CF children acquire environmental P. aeruginosa strains frequently. However, discordance between BAL and oropharyngeal strains raises questions over upper airway reservoirs and how to best determine eradication in non-expectorating children. (C) 2014 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：361 / 369

页数：9

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