The role of hydrolysis in biological effects of molybdenum cluster with DMSO ligands

被引：16

作者：

Pronina, Ekaterina, V ^{[1
]}

Pozmogova, Tatiana N. ^{[1
,2
,3
]}

Vorotnikov, Yuri A. ^{[1
]}

Ivanov, Anton A. ^{[1
]}

Shestopalov, Michael A. ^{[1
]}

机构：

[1] Nikolaev Inst Inorgan Chem SB RAS, 3 Acad Lavrentiev Ave, Novosibirsk 630090, Russia

[2] Inst Cytol & Genet SB RAS, SPF Vivarium, 10 Acad Lavrentieva Ave, Novosibirsk 630090, Russia

[3] Novosibirsk State Univ, 1 Pirogova St, Novosibirsk 630090, Russia

来源：

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2022年 / 27卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

Cluster compounds; Molybdenum; Hydrolysis; Cytotoxicity; Photoinduced cytotoxicity; NANOPARTICLES; COMPLEXES; LUMINESCENCE; POLYSTYRENE;

D O I：

10.1007/s00775-021-01914-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biological applications of octahedral molybdenum cluster complexes are complicated by their hydrolytic instability, since hydrolysis leads to irreversible changes in the structure and properties of these compounds. On the other hand, if such changes are thoroughly investigated and understood, the hydrolysis process can become an important tool for regulating specific biological effects of the clusters. In this work, we demonstrate how the luminescence and biological properties (cellular uptake, cytotoxicity in the dark and photodynamic effect) of highly unstable cluster complex [{Mo6I8}(DMSO)(6)](NO3)(4) change along with the degree of hydrolysis. Particularly, cluster solution preliminarily aged in water demonstrated lower dark and higher photoinduced cytotoxicity and higher cellular uptake in comparison with fresh solution.

引用

页码：111 / 119

页数：9

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