Fecal calprotectin and ulcerative colitis endoscopic activity index as indicators of mucosal healing in ulcerative colitis

被引：18

作者：

Taghvaei, Tarang ^{[1
]}

Maleki, Iradj ^{[1
]}

Nagshvar, Farshad ^{[2
]}

Fakheri, Hafez ^{[1
]}

Hosseini, Vahid ^{[1
]}

Valizadeh, Seyed Mohammad ^{[1
]}

Neishaboori, Hassan ^{[1
]}

机构：

[1] Mazandaran Univ Med Sci, Inflammatory Dis Upper Gastrointestinal Tract Res, Imam Khomeini Hosp, Sari 4816633131, Iran

[2] Mazandaran Univ Med Sci, Dept Pathol, Sari 4816633131, Iran

来源：

INTERNAL AND EMERGENCY MEDICINE | 2015年 / 10卷 / 03期

关键词：

Calprotectin; UCEIS; Mucosal healing; Ulcerative colitis; Inflammatory bowel disease; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL INFLAMMATION; NONINVASIVE MARKER; CLINICAL-TRIALS; RELAPSE; SEVERITY; LACTOFERRIN; PROTEINS; FECES;

D O I：

10.1007/s11739-014-1144-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ulcerative colitis (UC) is a chronic, idiopathic, inflammatory large bowel disease with recurrent variable periods of exacerbation. The aim of the current study is to evaluate the correlation of UCEIS with fecal calprotectin (FC) level to assess disease activity in UC patients in order to determine whether FC can prognosticate clinical outcome and disease activity of UC instead of colonoscopic evaluation. Our endoscopic investigations revealed the extension of UC as the following: proctitis (11.6 %), procto-sigmoiditis (18.5 %), left-sided colitis (15.8 %), extensive colitis (11.7 %), and normal endoscopy (42.4 %). Conclusively, we suggest that FC can be used as a reliable tool to evaluate disease activity in ulcerative colitis patients. Moreover, our findings indicate a significant correlation between FC level and mucosal healing.

引用

页码：321 / 328

页数：8

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