'Click' synthesis of cobalt bis(dicarbollide)-cholesterol conjugates

被引：15

作者：

Druzina, Anna A. ^{[1
]}

Shmalko, Akim, V ^{[1
]}

Andreichuk, Ekaterina P. ^{[1
,2
]}

Zhidkova, Olga B. ^{[1
]}

Kosenko, Irina D. ^{[1
]}

Semioshkin, Andrey ^{[1
,3
]}

Sivaev, Igor B. ^{[1
,4
]}

Mandal, Swadhin ^{[5
]}

Shen, Zheyu ^{[6
]}

Bregadze, Vladimir, I ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelentent Cpds, Moscow 119991, Russia

[2] DI Mendeleev Univ Chem Technol Russia, Moscow 125047, Russia

[3] Globalchempharm Co, Moscow 123001, Russia

[4] GV Plekhanov Russian Univ Econ, Moscow 117997, Russia

[5] Indian Inst Sci Educ & Res, Mohanpur 741246, India

[6] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China

来源：

MENDELEEV COMMUNICATIONS | 2019年 / 29卷 / 06期

基金：

俄罗斯基础研究基金会; 中国国家自然科学基金;

关键词：

NEUTRON-CAPTURE THERAPY; CHEMISTRY; CYCLOADDITION; DERIVATIVES; LIPOSOMES; DELIVERY;

D O I：

10.1016/j.mencom.2019.11.007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New conjugates of cholesterol and cobalt bis(dicarbollide) were synthesized using 'click' cycloaddition of 3 beta-(2-azidoethyl)cholest-5-ene and acetylene-equipped cobalt bis(dicarbollides). The synthesized boronated cholesterols can be of interest for liposomal drug delivery for boron neutron capture therapy of cancer.

引用

页码：628 / 630

页数：3

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