The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy

被引：44

作者：

Mbuagbaw, Lawrence ^{[1
]}

Thabane, Lahana ^{[2
,3
]}

Ongolo-Zogo, Pierre ^{[1
]}

Lester, Richard T. ^{[4
,5
]}

Mills, Edward ^{[6
]}

Volmink, Jimmy ^{[7
]}

Yondo, David ^{[1
]}

Essi, Marie Jose ^{[1
]}

Bonono-Momnougui, Renee-Cecile ^{[1
]}

Mba, Robert ^{[1
]}

Ndongo, Jean Serge ^{[1
]}

Nkoa, Francois C. ^{[1
]}

Ondoa, Henri Atangana ^{[1
]}

机构：

[1] Yaounde Cent Hosp, CDBPH, Yaounde, Cameroon

[2] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[3] St Josephs Healthcare, Biostat Unit, Father Sean OSullivan Res Ctr, Hamilton, ON, Canada

[4] Univ British Columbia, Dept Med, Div Infect Dis, Vancouver, BC, Canada

[5] British Columbia Ctr Dis Control, Vancouver, BC, Canada

[6] Univ Ottawa, Fac Hlth Sci, Ottawa, ON, Canada

[7] Univ Stellenbosch, Fac Hlth Sci, Cape Town, South Africa

来源：

TRIALS | 2011年 / 12卷

基金：

加拿大健康研究院;

关键词：

MEDICATION ADHERENCE; HIV; HIV/AIDS; HEALTH;

D O I：

10.1186/1745-6215-12-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: This trial aims at testing the efficacy of weekly reminder and motivational text messages, compared to usual care in improving adherence to Highly Active Antiretroviral Treatment in patients attending a clinic in Yaounde, Cameroon. Methods and Design: This is a single-centered randomized controlled single-blinded trial. A central computer generated randomization list will be generated using random block sizes. Allocation will be determined by sequentially numbered sealed opaque envelopes. 198 participants will either receive the mobile phone text message or usual care. Our hypothesis is that weekly motivational text messages can improve adherence to Highly Active Antiretroviral Treatment and other clinical outcomes in the control group by acting as a reminder, a cue to action and opening communication channels. Data will be collected at baseline, three months and six months. A blinded program secretary will send out text messages and record delivery. Our primary outcomes are adherence measured by the visual analogue scale, self report, and pharmacy refill data. Our secondary outcomes are clinical: weight, body mass index, opportunistic infections, all cause mortality and retention; biological: Cluster Designation 4 count and viral load; and quality of life. Analysis will be by intention-to-treat. Covariates and subgroups will be taken into account. Discussion: This trial investigates the potential of SMS motivational reminders to improve adherence to Highly Active Antiretroviral Treatment in Cameroon. The intervention targets non-adherence due to forgetfulness and other forms of non-adherence.

引用

页数：8

共 38 条

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