Comparative Efficacies of Tedizolid Phosphate, Linezolid, and Vancomycin in a Murine Model of Subcutaneous Catheter-Related Biofilm Infection Due to Methicillin-Susceptible and -Resistant Staphylococcus aureus

被引：19
|
作者：
Bayer, Arnold S. [1 ,2 ]
Abdelhady, Wessam [1 ]
Li, Liang [1 ]
Gonzales, Rachelle [1 ]
Xiong, Yan Q. [1 ,2 ]
机构：
[1] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 08期
关键词：
SKIN-STRUCTURE INFECTIONS; EXPERIMENTAL ENDOCARDITIS; MOUSE MODEL; OXAZOLIDINONE; ANTIBIOTICS; DAPTOMYCIN; TELAVANCIN; PNEUMONIA; MICE; RAT;
D O I：
10.1128/AAC.00880-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tedizolid, a novel oxazolidinone, exhibits bacteriostatic activity through inhibition of protein synthesis. The efficacies of tedizolid, linezolid, and vancomycin were compared in a murine catheter-related biofilm infection caused by methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA, respectively) strains engineered for bioluminescence. We observed significantly improved efficacy in terms of decreased S. aureus densities and bioluminescent signals in the tedizolid-treated group versus the linezolid-and vancomycin-treated groups in the model of infection caused by the MSSA and MRSA strains.
引用
收藏
页码：5092 / 5096
页数：5
相关论文
共 12 条
  • [1] Comparative Efficacies of Tedizolid Phosphate, Vancomycin, and Daptomycin in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Endocarditis
    Chan, Liana C.
    Basuino, Li
    Dip, Etyene C.
    Chambers, Henry F.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (06) : 3252 - 3256
  • [2] Comparative Efficacies of Human Simulated Exposures of Tedizolid and Linezolid against Staphylococcus aureus in the Murine Thigh Infection Model
    Keel, R. A.
    Tessier, P. R.
    Crandon, J. L.
    Nicolau, D. P.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (08) : 4403 - 4407
  • [3] Reduced Vancomycin Susceptibility in an In Vitro Catheter-Related Biofilm Model Correlates with Poor Therapeutic Outcomes in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus
    Abdelhady, Wessam
    Bayer, Arnold S.
    Seidl, Kati
    Nast, Cynthia C.
    Kiedrowski, Megan R.
    Horswill, Alexander R.
    Yeaman, Michael R.
    Xiong, Yan Q.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (03) : 1447 - 1454
  • [4] Pathogen-related factors affecting outcome of catheter-related bacteremia due to methicillin-susceptible Staphylococcus aureus in a Spanish multicenter study
    R. San-Juan
    D. Pérez-Montarelo
    E. Viedma
    A. Lalueza
    J. Fortún
    E. Loza
    M. Pujol
    C. Ardanuy
    I. Morales
    M. de Cueto
    E. Resino-Foz
    M. A. Morales-Cartagena
    M. Fernández-Ruiz
    A. Rico
    M. P. Romero
    M. Fernández de Mera
    F. López-Medrano
    M. Á. Orellana
    J. M. Aguado
    F. Chaves
    European Journal of Clinical Microbiology & Infectious Diseases, 2017, 36 : 1757 - 1765
  • [5] Pathogen-related factors affecting outcome of catheter-related bacteremia due to methicillin-susceptible Staphylococcus aureus in a Spanish multicenter study
    San-Juan, R.
    Perez-Montarelo, D.
    Viedma, E.
    Lalueza, A.
    Fortun, J.
    Loza, E.
    Pujol, M.
    Ardanuy, C.
    Morales, I.
    de Cueto, M.
    Resino-Foz, E.
    Morales-Cartagena, M. A.
    Fernandez-Ruiz, M.
    Rico, A.
    Romero, M. P.
    Fernandez de Mera, M.
    Lopez-Medrano, F.
    Orellana, M. A.
    Aguado, J. M.
    Chaves, F.
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2017, 36 (10) : 1757 - 1765
  • [6] Liposomal encapsulation of vancomycin improves killing of methicillin-resistant Staphylococcus aureus in a murine infection model
    Sande, Linette
    Sanchez, Marisel
    Montes, Joy
    Wolf, Andrea J.
    Morgan, Margie A.
    Omri, Abdelwahab
    Liu, George Y.
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (09) : 2191 - 2194
  • [7] Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection
    Kaku, Norihito
    Morinaga, Yoshitomo
    Takeda, Kazuaki
    Kosai, Kosuke
    Uno, Naoki
    Hasegawa, Hiroo
    Miyazaki, Taiga
    Izumikawa, Koichi
    Mukae, Hiroshi
    Yanagihara, Katsunori
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2016, 306 (06) : 421 - 428
  • [8] Comparative Study on the Antibacterial Activity and Efficacy of Linezolid and Vancomycin in Methicillin-Resistant Staphylococcus aureus Rat Pneumonia Model
    Hou, Sicong
    Zhou, Li
    Wu, Hongying
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2020, 10 (01) : 110 - 114
  • [9] Daptomycin and methicillin-resistant Staphylococcus aureus isolated from a catheter-related bloodstream infection: A case report
    Cavalcante F.S.
    Ferreira D.D.C.
    Chamon R.C.
    Da Costa T.M.
    Maia F.
    Barros E.M.
    Dantas T.S.
    Dos Santos K.R.N.
    BMC Research Notes, 7 (1)
  • [10] Host Gene Expression Profiling and In Vivo Cytokine Studies to Characterize the Role of Linezolid and Vancomycin in Methicillin-Resistant Staphylococcus aureus (MRSA) Murine Sepsis Model
    Sharma-Kuinkel, Batu K.
    Zhang, Yurong
    Yan, Qin
    Ahn, Sun Hee
    Fowler, Vance G., Jr.
    PLOS ONE, 2013, 8 (04):
12