Water-soluble conjugated polyelectrolyte with pendant glycocluster: Synthesis and its interaction with heparin

被引：28
作者：
Chen, Qi [1 ]
Cui, Yi [1 ,2 ]
Cao, Jie [3 ]
Han, Bao-Hang [1 ]
机构：
[1] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
[3] Beijing Inst Technol, Dept Chem, Beijing 100081, Peoples R China
来源：
POLYMER | 2011年 / 52卷 / 02期
基金：
美国国家科学基金会;
关键词：
Conjugated polymers; Fluorescence; Glucosamine hydrochloride; DENDRONIZED POLYFLUORENES; INDUCED THROMBOCYTOPENIA; SENSITIVE DETECTION; CARBAZOLE GROUPS; ENERGY-TRANSFER; LABELED DNA; FLUORESCENT; POLYMERS; ETHYNYLENE); BACTERIA;
D O I：
10.1016/j.polymer.2010.11.048
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A novel fluorescent conjugated polyelectrolyte with pendant glucosamine hydrochloride clusters was prepared through Cu(I)-catalyzed azide/alkyne "click" ligation and Suzuki coupling polymerization. Compared with monosugar-functionalized conjugated polymer, the water-solubility and fluorescence quantum yield of the glycocluster-containing polymer (P-3) were significantly improved. As a glucosamine-containing cationic fluorescent polyelectrolyte, the water-soluble fluorescent polymer can interact with heparin through electrostatic bindings, which induce great fluorescence quenching of P-3 due to the polymer aggregation. Furthermore, upon treatment of the P-3 heparin ensemble with protamine, the fluorescence emission of P-3 recovered since the protamine possesses a competitively strong binding affinity to the heparin and thus results in the release of the fluorescent glycopolymer P-3 from the P-3 heparin ensemble. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：383 / 390
页数：8
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