Water-soluble conjugated polyelectrolyte with pendant glycocluster: Synthesis and its interaction with heparin

被引：28

作者：

Chen, Qi ^{[1
]}

Cui, Yi ^{[1
,2
]}

Cao, Jie ^{[3
]}

Han, Bao-Hang ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

[3] Beijing Inst Technol, Dept Chem, Beijing 100081, Peoples R China

来源：

POLYMER | 2011年 / 52卷 / 02期

基金：

美国国家科学基金会;

关键词：

Conjugated polymers; Fluorescence; Glucosamine hydrochloride; DENDRONIZED POLYFLUORENES; INDUCED THROMBOCYTOPENIA; SENSITIVE DETECTION; CARBAZOLE GROUPS; ENERGY-TRANSFER; LABELED DNA; FLUORESCENT; POLYMERS; ETHYNYLENE); BACTERIA;

D O I：

10.1016/j.polymer.2010.11.048

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel fluorescent conjugated polyelectrolyte with pendant glucosamine hydrochloride clusters was prepared through Cu(I)-catalyzed azide/alkyne "click" ligation and Suzuki coupling polymerization. Compared with monosugar-functionalized conjugated polymer, the water-solubility and fluorescence quantum yield of the glycocluster-containing polymer (P-3) were significantly improved. As a glucosamine-containing cationic fluorescent polyelectrolyte, the water-soluble fluorescent polymer can interact with heparin through electrostatic bindings, which induce great fluorescence quenching of P-3 due to the polymer aggregation. Furthermore, upon treatment of the P-3 heparin ensemble with protamine, the fluorescence emission of P-3 recovered since the protamine possesses a competitively strong binding affinity to the heparin and thus results in the release of the fluorescent glycopolymer P-3 from the P-3 heparin ensemble. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：383 / 390

页数：8

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