Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese-A 4-and 13-year descriptive epidemiologic study

被引：7

作者：

Otsuka, Rei ^{[1
]}

Kato, Yuki ^{[1
]}

Imai, Tomoko ^{[1
,2
]}

Ando, Fujiko ^{[1
,3
]}

Shimokata, Hiroshi ^{[1
,4
]}

机构：

[1] Natl Ctr Geriatr & Gerontol, Natl Inst Longev Sci NILS LSA, Sect Longitudinal Study Aging, Obu, Aichi 4748511, Japan

[2] Doshisha Womens Coll Liberal Arts, Fac Human Life & Sci, Kamigyo Ku, Kyoto, Japan

[3] Aichi Shukutoku Univ, Fac Hlth & Med Sci, Nagakute, Aichi, Japan

[4] Nagoya Univ Art & Sci, Grad Sch Nutr Sci, Nisshin, Aichi, Japan

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2015年 / 94卷

关键词：

Eicosapentaenoic acid; Docosahexaenoic acid; Arachidonic acid; Japanese; Descriptive epidemiologic study; POLYUNSATURATED FATTY-ACIDS; AGE-RELATED-CHANGES; WHOLE-BLOOD; DIETARY-FAT; PLASMA; N-3; MEN; SUPPLEMENTATION; POPULATION; BRAIN;

D O I：

10.1016/j.plefa.2014.11.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cross-sectional studies have shown age-related increases in blood docosahexaenoic and eicosapentaenoic acid and decreases in arachidonic acid. We describe serum docosahexaenoic, eicosapentaenoic, and arachidonic acid concentrations over 13 years (1997-2012) across four study waves and serum fatty acid composition over 4 years (2006-2012) between two study waves according to age groups by sex in the same subjects. We included 443 men and 435 women aged 40-79 years at baseline. Serum arachidonic acid concentrations increased in all sex and age groups over 13 years, and eicosapentaenoic or docosahexaenoic acid concentrations increased in males and females who were younger and middle-aged at baseline. Only serum arachidonic acid composition increased over 4 years in men and women who were 40-69 years at baseline, even after adjustment for arachidonic acid intake. These findings suggest a secular increase trend in serum arachidonic acid levels over 13 years among randomly selected community-dwelling middle-aged and elderly Japanese. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：35 / 42

页数：8

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