Modeling nucleotide excision repair and its impact on UV-induced mutagenesis during SOS-response in bacterial cells

被引：7

作者：

Bugay, Aleksandr N. ^{[1
]}

Krasavin, Evgeny A. ^{[1
]}

Parkhomenko, Aleksandr Yu. ^{[1
]}

Vasilyeva, Maria A. ^{[1
]}

机构：

[1] Joint Inst Nucl Res, Radiat Biol Lab, Dubna 141980, Moscow Region, Russia

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2015年 / 364卷

关键词：

UV mutagenesis; Mathematical modeling; DNA-DAMAGE RESPONSE; ESCHERICHIA-COLI; POLYMERASE-V; COPROTEASE ACTIVITIES; BIOCHEMICAL BASIS; HELICASE-II; PROTEIN; GENE; CLEAVAGE; UMUD;

D O I：

10.1016/j.jtbi.2014.08.041

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A model of the UV-induced mutation process in Escherichia coli bacteria has been developed taking into account the whole sequence of molecular events starting from initial photo-damage and finishing with the fixation of point mutations. The wild-type phenotype bacterial cells are compared with UV-sensitive repair-deficient mutant cells. Attention is mainly paid to excision repair system functioning as regards induced mutagenesis. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：7 / 20

页数：14

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