Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells

被引：40
作者：
Abud, Helen E. [1 ,2 ]
Chan, Wing Hei [1 ,2 ]
Jarde, Thierry [1 ,2 ]
机构：
[1] Monash Univ, Dept Anat & Dev Biol, Clayton, Vic, Australia
[2] Monash Biomed Discovery Inst, Dev & Stem Cells Program, Clayton, Vic, Australia
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
Epidermal Growth Factor; neuregulin; 1; intestinal stem cells; signaling; niche; ErbB; tissue regeneration; organoids; GROWTH-FACTOR-RECEPTOR; MICE LACKING; CARDIAC DEVELOPMENT; PANETH CELLS; HB-EGF; MOUSE; REGENERATION; ERBB3; AMPHIREGULIN; NEUREGULIN;
D O I：
10.3389/fcell.2021.685665
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in vivo and is routinely added to the culture medium to support the growth of intestinal organoids ex vivo. The recent identification of diverse stromal cell populations that reside underneath intestinal crypts has enabled the characterization of key growth factor cues supplied by these cells. The nature of these signals and how they are delivered to drive intestinal epithelial development, daily homeostasis and tissue regeneration following injury are being investigated. It is clear that aside from EGF, other ligands of the family, including Neuregulin 1 (NRG1), have distinct roles in supporting the function of intestinal stem cells through the ErbB pathway.
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页数：9
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