DNA double-strand breaks, chromosomal rearrangements, and genomic instability

被引：88

作者：

Morgan, WF

Corcoran, J

Hartmann, I

Kaplan, MI

Limoli, CL

Ponnaiya, B

机构：

[1] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

[4] Univ Calif San Francisco, Grad Grp Biophys, San Francisco, CA 94143 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1998年 / 404卷 / 1-2期

关键词：

DNA double-strand break; chromosomal rearrangement; genomic instability;

D O I：

10.1016/S0027-5107(98)00104-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA double-strand breaks can lead to chromosomal rearrangements at the first mitosis after exposure to the DNA strand-breaking agent. The evidence suggests a number of different pathways for DNA double-strand break rejoining in mammalian cells, but it is unclear what factors determine the fate of the induced break and whether or not it will lead to chromosomal rearrangement. If a cell does survive and proliferate after DNA cleavage, delayed chromosomal instability can be observed in the clonal descendants of the exposed cell. Most, but not all DNA double-strand breaking agents are effective at inducing this delayed chromosomal instability. In this paper, we review the evidence for the role of the DNA double-strand break in directly induced and delayed chromosomal rearrangements. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：125 / 128

页数：4

共 15 条

[1] ANALYSIS OF RESTRICTION ENZYME-INDUCED DNA DOUBLE-STRAND BREAKS IN CHINESE-HAMSTER OVARY CELLS BY PULSED-FIELD GEL-ELECTROPHORESIS - IMPLICATIONS FOR CHROMOSOME-DAMAGE [J].