Novel nonantibiotic therapies for pneumonia - Cytokines and host defense

被引:35
作者
Nelson, S [1 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Med, Pulm Crit Care Med Sect, New Orleans, LA 70112 USA
关键词
cytokines; granulocyte colony-stimulating factor; inflammatory response; interleukins; pneumonia; tumor necrosis factor;
D O I
10.1378/chest.119.2_suppl.419S
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Effective host defense against bacterial infection is dependent on the activation and recruitment of phagocytic cells. The initiation, maintenance, and resolution of this inflammatory response in the setting of bacterial pneumonia is dependent on the expression of cytokines. As the complexities of the host-pathogen interaction are further dissected and unraveled, immunologic manipulation of cytokine expression will likely become an important adjuvant therapy in the treatment of serious lung infections.
引用
收藏
页码:419S / 425S
页数:7
相关论文
共 40 条
  • [1] PROTECTIVE EFFECTS OF TUMOR NECROSIS FACTOR IN EXPERIMENTAL LEGIONELLA-PNEUMOPHILA INFECTIONS OF MICE VIA ACTIVATION OF PMN FUNCTION
    BLANCHARD, DK
    DJEU, JY
    KLEIN, TW
    FRIEDMAN, H
    STEWART, WE
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1988, 43 (05) : 429 - 435
  • [2] COMPARTMENTALIZATION OF THE ACUTE CYTOKINE RESPONSE IN HUMANS AFTER INTRAVENOUS ENDOTOXIN ADMINISTRATION
    BOUJOUKOS, AJ
    MARTICH, GD
    SUPINSKI, E
    SUFFREDINI, AF
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1993, 74 (06) : 3027 - 3033
  • [3] Compartmentalized IL-8 and elastase release within the human lung in unilateral pneumonia
    Boutten, A
    Dehoux, MS
    Seta, N
    Ostinelli, J
    Venembre, P
    Crestani, B
    Dombret, MC
    Durand, G
    Aubier, M
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (01) : 336 - 342
  • [4] BRUNDA MJ, 1994, J LEUKOCYTE BIOL, V55, P280
  • [5] ENDOTOXIN-INDUCED SERUM FACTOR THAT CAUSES NECROSIS OF TUMORS
    CARSWELL, EA
    OLD, LJ
    KASSEL, RL
    GREEN, S
    FIORE, N
    WILLIAMSON, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (09) : 3666 - 3670
  • [6] Time to resolution of morbidity: An endpoint for assessing the clinical cure of community-acquired pneumonia
    Daifuku, R
    Movahhed, H
    Fotheringham, N
    Bear, MB
    Nelson, S
    [J]. RESPIRATORY MEDICINE, 1996, 90 (10) : 587 - 592
  • [7] GRANULOCYTE-COLONY-STIMULATING FACTOR - ROLE AND RELATIONSHIPS IN INFECTIOUS-DISEASES
    DALE, DC
    LILES, WC
    SUMMER, WR
    NELSON, S
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (04) : 1061 - 1075
  • [8] COMPARTMENTALIZED CYTOKINE PRODUCTION WITHIN THE HUMAN LUNG IN UNILATERAL PNEUMONIA
    DEHOUX, MS
    BOUTTEN, A
    OSTINELLI, J
    SETA, N
    DOMBRET, MC
    CRESTANI, B
    DESCHENES, M
    TROUILLET, JL
    AUBIER, M
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 150 (03) : 710 - 716
  • [9] Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
    Docke, WD
    Randow, F
    Syrbe, U
    Krausch, D
    Asadullah, K
    Reinke, P
    VolK, HD
    Kox, W
    [J]. NATURE MEDICINE, 1997, 3 (06) : 678 - 681
  • [10] THE ALVEOLAR MACROPHAGE
    FELS, AOS
    COHN, ZA
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1986, 60 (02) : 353 - 369