Reconfiguration of brain network architecture to support executive control in aging

被引：55
作者：
Gallen, Courtney L. [1 ]
Turner, Gary R. [2 ]
Adnan, Areeba [2 ]
D'Esposito, Mark [1 ,3 ]
机构：
[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, 132 Barker Hall 3190, Berkeley, CA 94720 USA
[2] York Univ, Sherman Hlth Sci Res Ctr, Dept Psychol, Toronto, ON M3J 2R7, Canada
[3] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA
来源：
NEUROBIOLOGY OF AGING | 2016年 / 44卷
基金：
美国国家卫生研究院;
关键词：
Aging; Graph theory; Modularity; Resting state; Working memory; STATE FUNCTIONAL CONNECTIVITY; AGE-RELATED-CHANGES; PREFRONTAL CORTEX; WORKING-MEMORY; COGNITIVE NEUROSCIENCE; DEFAULT NETWORK; TOP; ORGANIZATION; MODULARITY; UNDERLIES;
D O I：
10.1016/j.neurobiolaging.2016.04.003
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging is accompanied by declines in executive control abilities and changes in underlying brain network architecture. Here, we examined brain networks in young and older adults during a task-free resting state and an N-back task and investigated age-related changes in the modular network organization of the brain. Compared with young adults, older adults showed larger changes in network organization between resting state and task. Although young adults exhibited increased connectivity between lateral frontal regions and other network modules during the most difficult task condition, older adults also exhibited this pattern of increased connectivity during less-demanding task conditions. Moreover, the increase in between-module connectivity in older adults was related to faster task performance and greater fractional anisotropy of the superior longitudinal fasciculus. These results demonstrate that older adults who exhibit more pronounced network changes between a resting state and task have better executive control performance and greater structural connectivity of a core frontal-posterior white matter pathway. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：42 / 52
页数：11
相关论文
共 63 条
[1]   Disruption of large-scale brain systems in advanced aging [J].
Andrews-Hanna, Jessica R. ;
Snyder, Abraham Z. ;
Vincent, Justin L. ;
Lustig, Cindy ;
Head, Denise ;
Raichle, Marcus E. ;
Buckner, Randy L. .
NEURON, 2007, 56 (05) :924-935
[2]  
[Anonymous], NEUROIMAGE
[3]  
[Anonymous], FRONT NEUROINFORM
[4]   Prefrontal modulation of visual processing in humans [J].
Barceló, F ;
Suwazono, S ;
Knight, RT .
NATURE NEUROSCIENCE, 2000, 3 (04) :399-403
[5]   DISCONNECTED AGING: CEREBRAL WHITE MATTER INTEGRITY AND AGE-RELATED DIFFERENCES IN COGNITION [J].
Bennett, I. J. ;
Madden, D. J. .
NEUROSCIENCE, 2014, 276 :187-205
[6]   Decreased segregation of brain systems across the healthy adult lifespan [J].
Chan, Micaela Y. ;
Park, Denise C. ;
Savalia, Neil K. ;
Petersen, Steven E. ;
Wig, Gagan S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (46) :E4997-E5006
[7]   Contribution of human prefrontal cortex to delay performance [J].
Chao, LL ;
Knight, RT .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1998, 10 (02) :167-177
[8]   Training of goal-directed attention regulation enhances control over neural processing for individuals with brain injury [J].
Chen, Anthony J. -W. ;
Novakovic-Agopian, Tatjana ;
Nycum, Terrence J. ;
Song, Shawn ;
Turner, Gary R. ;
Hills, Nancy K. ;
Rome, Scott ;
Abrams, Gary M. ;
D'Esposito, Mark .
BRAIN, 2011, 134 :1541-1554
[9]   Age-related alterations in the modular organization of structural cortical network by using cortical thickness from MRI [J].
Chen, Zhang J. ;
He, Yong ;
Rosa-Neto, Pedro ;
Gong, Gaolang ;
Evans, Alan C. .
NEUROIMAGE, 2011, 56 (01) :235-245
[10]   Deficit in switching between functional brain networks underlies the impact of multitasking on working memory in older adults [J].
Clapp, Wesley C. ;
Rubens, Michael T. ;
Sabharwal, Jasdeep ;
Gazzaley, Adam .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (17) :7212-7217
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