Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions

被引：48

作者：

Chen, Jinjin ^{[1
]}

Chang, Dan ^{[1
]}

Xiao, Fuhong ^{[1
]}

Deng, Guo-Jun ^{[1
,2
]}

机构：

[1] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China

[2] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

来源：

GREEN CHEMISTRY | 2018年 / 20卷 / 24期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

OXIDATIVE DECARBOXYLATIVE AMINATION; ASYMMETRIC POVAROV REACTION; CATALYZED CASCADE SYNTHESIS; 3-COMPONENT SYNTHESIS; 2-SUBSTITUTED QUINAZOLINES; ENANTIOSELECTIVE SYNTHESIS; ARYLDIAZONIUM SALTS; EFFICIENT SYNTHESIS; SOLVENT-FREE; ANNULATION;

D O I：

10.1039/C8GC02654H

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A four-component procedure for the preparation of substituted quinazolines from anilines, aromatic aldehydes and ammonium iodide is described. The C-H bond ortho to the amino group in anilines was directly functionalized under metal-free conditions. Two aldehydes were involved in this reaction and ammonium iodide was used as one of the nitrogen sources. This reaction provides a strategy for the facile construction of substituted quinazolines from simple anilines and other readily available reactants.

引用

页码：5459 / 5463

页数：5

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