Eosinophilic Asthma

被引：69
作者：
Nelson, Ryan K. [1 ]
Bush, Andrew [2 ,3 ]
Stokes, Jeffrey [4 ]
Nair, Parameswaran [5 ,6 ]
Akuthota, Praveen [1 ]
机构：
[1] Univ Calif San Diego, Dept Med, Div Pulm Crit Care & Sleep Med, 9500 Gilman Dr,MC 7381, La Jolla, CA 92093 USA
[2] Royal Brompton Hosp, Dept Paediat Resp Med, London, England
[3] Imperial Sch Med, Natl Heart & Lung Inst, London, England
[4] Washington Univ, Sch Med, Dept Pediat, Div Allergy Immunol & Pulm Med, St Louis, MO 63110 USA
[5] McMaster Univ, Dept Med, Div Respirol, Hamilton, ON, Canada
[6] St Josephs Healthcare, Firestone Inst Resp Hlth, Hamilton, ON, Canada
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2020年 / 8卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Asthma; Eosinophils; Aspirin-exacerbated respiratory disease; Endotypes; EXACERBATED RESPIRATORY-DISEASE; DOUBLE-BLIND; RHINOSINUSITIS-ASTHMA; CLUSTER-ANALYSIS; ALLERGIC-ASTHMA; URINARY LTE4; NASAL POLYPS; MEPOLIZUMAB; PLACEBO; PHENOTYPES;
D O I：
10.1016/j.jaip.2019.11.024
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The T(H)2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by T(H)2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined. (C) 2019 American Academy of Allergy, Asthma & Immunology
引用
收藏
页码：465 / 473
页数：9
相关论文
共 91 条
  • [81] A retrospective analysis of mepolizumab in subjects with aspirin-exacerbated respiratory disease
    Tuttle, Katherine L.
    Buchheit, Kathleen M.
    Laidlaw, Tanya M.
    Cahill, Katherine N.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2018, 6 (03) : 1045 - 1047
  • [82] Consistency of sputum eosinophilia in difficult-to-treat asthma: A 5-year follow-up study
    van Veen, Ilonka H.
    ten Brinke, Anneke
    Gauw, Stefanie A.
    Sterk, Peter J.
    Rabe, Klaus F.
    Bel, Elisabeth H.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (03) : 615 - 617
  • [83] Reslizumab and eosinophilic Asthma: One Step Closer to Precision Medicine?
    Varricchi, Gilda
    Senna, Gianenrico
    Loffredo, Stefania
    Bagnasco, Diego
    Ferrando, Matteo
    Canonica, Giorgio Walter
    [J]. FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [84] Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis
    Wechsler, M. E.
    Akuthota, P.
    Jayne, D.
    Khoury, P.
    Klion, A.
    Langford, C. A.
    Merkel, P. A.
    Moosig, F.
    Specks, U.
    Cid, M. C.
    Luqmani, R.
    Brown, J.
    Mallett, S.
    Philipson, R.
    Yancey, S. W.
    Steinfeld, J.
    Weller, P. F.
    Gleich, G. J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (20) : 1921 - 1932
  • [85] Efficacy of Reslizumab with Asthma, Chronic Sinusitis with Nasal Polyps and Elevated Blood Eosinophils
    Weinstein, Steven F.
    Germinaro, Matthew
    Bardin, Philip
    Korn, Stephanie
    Bateman, Eric Donn
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (02) : AB86 - AB86
  • [86] Asthma: defining of the persistent adult phenotypes
    Wenzel, Sally E.
    [J]. LANCET, 2006, 368 (9537) : 804 - 813
  • [87] Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    Wenzel, SE
    Schwartz, LB
    Langmack, EL
    Halliday, JL
    Trudeau, JB
    Gibbs, RL
    Chu, HW
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (03) : 1001 - 1008
  • [88] Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data
    Wu, Wei
    Bleecker, Eugene
    Moore, Wendy
    Busse, William W.
    Castro, Mario
    Chung, Kian Fan
    Calhoun, William J.
    Erzurum, Serpil
    Gaston, Benjamin
    Israel, Elliot
    Curran-Everett, Douglas
    Wenzel, Sally E.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (05) : 1280 - 1288
  • [89] Biomarkers for severe eosinophilic asthma
    Yancey, Steven W.
    Keene, Oliver N.
    Albers, Frank C.
    Ortega, Hector
    Bates, Stewart
    Bleecker, Eugene R.
    Pavord, Ian
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (06) : 1509 - 1518
  • [90] Innate lymphoid cells and asthma
    Yu, Sanhong
    Kim, Hye Young
    Chang, Ya-Jen
    DeKruyff, Rosemarie H.
    Umetsu, Dale T.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (04) : 943 - 950
12345678910