Eosinophilic Asthma

被引：69
作者：
Nelson, Ryan K. [1 ]
Bush, Andrew [2 ,3 ]
Stokes, Jeffrey [4 ]
Nair, Parameswaran [5 ,6 ]
Akuthota, Praveen [1 ]
机构：
[1] Univ Calif San Diego, Dept Med, Div Pulm Crit Care & Sleep Med, 9500 Gilman Dr,MC 7381, La Jolla, CA 92093 USA
[2] Royal Brompton Hosp, Dept Paediat Resp Med, London, England
[3] Imperial Sch Med, Natl Heart & Lung Inst, London, England
[4] Washington Univ, Sch Med, Dept Pediat, Div Allergy Immunol & Pulm Med, St Louis, MO 63110 USA
[5] McMaster Univ, Dept Med, Div Respirol, Hamilton, ON, Canada
[6] St Josephs Healthcare, Firestone Inst Resp Hlth, Hamilton, ON, Canada
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2020年 / 8卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Asthma; Eosinophils; Aspirin-exacerbated respiratory disease; Endotypes; EXACERBATED RESPIRATORY-DISEASE; DOUBLE-BLIND; RHINOSINUSITIS-ASTHMA; CLUSTER-ANALYSIS; ALLERGIC-ASTHMA; URINARY LTE4; NASAL POLYPS; MEPOLIZUMAB; PLACEBO; PHENOTYPES;
D O I：
10.1016/j.jaip.2019.11.024
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The T(H)2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by T(H)2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined. (C) 2019 American Academy of Allergy, Asthma & Immunology
引用
收藏
页码：465 / 473
页数：9
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