Mechanisms underlying enhanced IgA production in Peyer's patch cells by membrane vesicles derived from Lactobacillus sakei

被引：19
作者：
Miyoshi, Yuki [1 ,2 ,3 ]
Saika, Azusa [2 ,3 ,4 ]
Nagatake, Takahiro [2 ,3 ]
Matsunaga, Ayu [2 ,3 ,5 ]
Kunisawa, Jun [2 ,3 ,4 ]
Katakura, Yoshio [6 ]
Yamasaki-Yashiki, Shino [2 ,3 ,6 ]
机构：
[1] Kansai Univ, Grad Sch Sci & Engn, Chem Mat & Bioengn Major, Suita, Osaka, Japan
[2] Natl Inst Biomed Innovat Hlth & Nutr, Lab Vaccine Mat, Ctr Vaccine & Adjuvant Res, Ibaraki, Osaka, Japan
[3] Natl Inst Biomed Innovat Hlth & Nutr, Lab Gut Environm Syst, Ibaraki, Osaka, Japan
[4] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka, Japan
[5] Azabu Univ, Sch Life & Environm Sci, Dept Food & Life Sci, Sagamihara, Kanagawa, Japan
[6] Kansai Univ, Fac Chem Mat & Bioengn, Dept Life Sci & Biotechnol, Suita, Osaka, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2021年 / 85卷 / 06期
基金：
日本学术振兴会;
关键词：
lactic acid bacteria; membrane vesicle; gut immunity; IgA; Peyer's patches; LACTIC-ACID BACTERIA; DENDRITIC CELLS; SECRETION;
D O I：
10.1093/bbb/zbab065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We analyzed the mechanisms underlying enhanced IgA production in the cells of Peyer's patch cells via membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC 15893. Depletion of CD11c(+) cells from Peyer's patch cells suppressed the enhanced IgA production mediated by membrane vesicles. Meanwhile, the stimulation of bone-marrow-derived dendritic cells with membrane vesicles increased gene expression of inducible nitric oxide synthase, retinaldehyde dehydrogenase 2, and several inflammatory cytokines. The production of nitric oxide and interleukin (IL)-6 by membrane vesicle stimulation was induced via Toll-like receptor 2 on bone marrow-derived dendritic cells. Inhibition of inducible nitric oxide synthase and retinaldehyde dehydrogenase 2, as well as the neutralization of IL-6 in Peyer's patch cells, suppressed the enhanced IgA production by membrane vesicle stimulation. Hence, nitric oxide, retinoic acid, and IL-6 induced by membrane vesicles play crucial roles in the enhanced IgA production elicited by membrane vesicles in Peyer's patch cells.
引用
收藏
页码：1536 / 1545
页数：10
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