tRNA biology charges to the front

被引：621

作者：

Phizicky, Eric M. ^{[1
]}

Hopper, Anita K. ^{[2
]}

机构：

[1] Univ Rochester, Sch Med, Ctr RNA Biol, Dept Biochem & Biophys, Rochester, NY 14642 USA

[2] Ohio State Univ, Dept Mol Genet, Ctr RNA Biol, Columbus, OH 43210 USA

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 17期

关键词：

Cleavage; modifications; processing; splicing; tRNA; trafficking; turnover; YEAST TRANSFER-RNA; POLYMERASE-III TRANSCRIPTION; MITOCHONDRIAL TRANSFER-RNA; CYTOPLASMIC TRANSFER-RNAS; PRECURSOR TRANSFER-RNAS; SACCHAROMYCES-CEREVISIAE TRNA(HIS); 3' PROCESSING ENDORIBONUCLEASE; KLUYVEROMYCES-LACTIS ZYMOCIN; PHENYLALANINE TRANSFER-RNA; HISTIDINE TRANSFER-RNA;

D O I：

10.1101/gad.1956510

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

tRNA biology has come of age, revealing an unprecedented level of understanding and many unexpected discoveries along the way. This review highlights new findings on the diverse pathways of tRNA maturation, and on the formation and function of a number of modifications. Topics of special focus include the regulation of tRNA biosynthesis, quality control tRNA turnover mechanisms, widespread tRNA cleavage pathways activated in response to stress and other growth conditions, emerging evidence of signaling pathways involving tRNA and cleavage fragments, and the sophisticated intracellular tRNA trafficking that occurs during and after biosynthesis.

引用

页码：1832 / 1860

页数：29

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