Intrinsic polarity of mammalian neuroepithelial cells

被引：171

作者：

Chenn, A ^{[1
]}

Zhang, YA ^{[1
]}

Chang, BT ^{[1
]}

McConnell, SK ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 1998年 / 11卷 / 04期

关键词：

D O I：

10.1006/mcne.1998.0680

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Progenitor cells in the mammalian forebrain can undergo either symmetric or asymmetric cell divisions by varying their cleavage orientation. In asymmetric divisions, cells distribute apically and basally localized proteins differentially to their daughters. Here we explore the intrinsic polarity of neuroepithelial cells in the developing telencephalon. Actin microfilaments are concentrated epically, forming beltlike structures that encircle spots of gamma-tubulin immunoreactivity. Staining for N-cadherin, beta-catenin, and the tyrosine kinase substrates pp120 and paxillin is also enriched at the lumenal surface, presumably due to the localization of these proteins at adherens junctions. Phosphotyrosine immunoreactivity is concentrated apically in rings, suggesting that adherens junctions are enriched for signaling molecules. In mitotic cells it appears that adherens junction proteins and phosphotyrosine immunoreactivity may be inherited either symmetrically or asymmetrically, depending on the cell's cleavage orientation during mitosis. The differential inheritance of junctional proteins may determine whether a daughter cell can respond to extrinsic signals after mitosis.

引用

页码：183 / 193

页数：11

共 48 条

[1] Loss of occludin and functional tight junctions, but not ZO-1, during neural tube closure - Remodeling of the neuroepithelium prior to neurogenesis [J].