Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte-macrophages

被引：55

作者：

Muller, K ^{[1
]}

Hardwick, SJ ^{[1
]}

Marchant, CE ^{[1
]}

Law, NS ^{[1
]}

Waeg, G ^{[1
]}

Esterbauer, H ^{[1
]}

Carpenter, KLH ^{[1
]}

Mitchinson, MJ ^{[1
]}

机构：

[1] GRAZ UNIV,INST BIOCHEM,A-8010 GRAZ,AUSTRIA

来源：

FEBS LETTERS | 1996年 / 388卷 / 2-3期

关键词：

aldehydes; cytotoxicity; chemotaxis; monocyte-macrophage (human); oxidised LDL; atherosclerosis;

D O I：

10.1016/0014-5793(96)00559-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have investigated the cytotoxic and chemotactic potencies of malondialdehyde (MDA), hexanal, 4-hydroxyhexenal (HHE), 4-hydroxynonenal (HNE) and 4-hydroxyoctenal (HOE), which are aldehydes found in oxidised low density lipoprotein (LDL), for human monocyte-macrophages. They were toxic in the following order: hexanal < HHE = HOE < HNE. HNE was toxic at 20 mu M and chemotactic at 2.5 mu M. The other aldehydes tested had no chemoattractant activity, Our results suggest that HNE arising from LDL oxidation could attract monocytes into the human atherosclerotic lesion. A direct cytotoxic role of aldehydes in foam cell death in the lesion is less likely.

引用

页码：165 / 168

页数：4

共 35 条

[1] MINIMALLY MODIFIED LOW-DENSITY-LIPOPROTEIN STIMULATES MONOCYTE ENDOTHELIAL INTERACTIONS [J].