Advances in asthma in 2017: Mechanisms, biologics, and genetics

被引：30

作者：

Grayson, Mitchell H. ^{[1
]}

Feldman, Scott ^{[2
]}

Prince, Benjamin T. ^{[1
]}

Patel, Priya J. ^{[2
]}

Matsui, Elizabeth C. ^{[3
]}

Apter, Andrea J. ^{[2
]}

机构：

[1] Ohio State Univ, Coll Med, Div Allergy & Immunol, Dept Pediat,Nationwide Childrens Hosp, Columbus, OH USA

[2] Univ Penn, Sch Med, Dept Med, Sect Allergy & Immunol,Div Pulm Allergy Crit Care, Philadelphia, PA 19104 USA

[3] Univ Texas Austin, Dept Populat Hlth, Dell Med Sch, Austin, TX 78712 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2018年 / 142卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Asthma; airway hyperreactivity; asthma biomarkers; asthma phenotypes; genetics; environment; respiratory viruses; allergens; eosinophils; helper T cells; B cells; innate lymphoid cells; neutrophils; biologic therapies; microbiome; CHILDHOOD ASTHMA; POOLED ANALYSIS; DOUBLE-BLIND; AIRWAY; LUNG; SENSITIZATION; ADULTS; INTERVENTION; RISK; INFLAMMATION;

D O I：

10.1016/j.jaci.2018.08.033

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they can influence the clinical delivery of asthma care. After this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. Finally, we conclude with a discussion of advances in health literacy and how they will affect asthma care.

引用

页码：1423 / 1436

页数：14

共 95 条

[61] Monocyte chemotactic protein-induced protein 1 controls allergic airway inflammation by suppressing IL-5-producing TH2 cells through the Notch/Gata3 pathway [J].

Peng, Hui ;

Ning, Huan ;

Wang, Qinghong ;

Lu, Wenbao ;

Chang, Yingzi ;

Wang, Tony T. ;

Lai, Jinping ;

Kolattukudy, Pappachan E. ;

Hou, Rong ;

Hoft, Daniel F. ;

Dykewicz, Mark S. ;

Liu, Jianguo .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018, 142 (02) :582-+

[62] Biologic Therapy and Novel Molecular Targets of Severe Asthma [J].

Pepper, Amber N. ;

Renz, Harald ;

Casale, Thomas B. ;

Garn, Holger .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2017, 5 (04) :909-916

[63] The Health Effects of Electronic Cigarettes Reply [J].

Dinakar, Chitra ;

O'Connor, George T. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (26) :2608-2609

[64] CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling [J].

Qiao, Yongkang ;

Tam, John Kit Chung ;

Tan, Sheryl S. L. ;

Tai, Yee Kit ;

Chin, Chin Yein ;

Stewart, Alastair G. ;

Ashman, Leonie ;

Sekiguchi, Kiyotoshi ;

Langenbach, Shenna Y. ;

Stelmack, Gerald ;

Halayko, Andrew J. ;

Tran, Thai .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (01) :82-+

[65] Differential connectivity of gene regulatory networks distinguishes corticosteroid response in asthma [J].

Qiu, Weiliang ;

Guo, Feng ;

Glass, Kimberly ;

Yuan, Guo Cheng ;

Quackenbush, John ;

Zhou, Xiaobo ;

Tantisira, Kelan G. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018, 141 (04) :1250-1258

[66]

Rabito FA, 2017, J ALLERGY CLIN IMMUN, V140, P565, DOI [10.1016/j.jaci.2016.10.019, 10.1016/j.jaci.2016.12.221]

[67] Identification of IL-17F/frequent exacerbator endotype in asthma [J].

Ricciardolo, Fabio L. M. ;

Sorbello, Valentina ;

Folino, Anna ;

Gallo, Fabio ;

Massaglia, Gian Mario ;

Favata, Gabriella ;

Conticello, Salvatore ;

Vallese, Davide ;

Gani, Federica ;

Malerba, Mario ;

Folkerts, Gert ;

Rolla, Giovanni ;

Profita, Mirella ;

Mauad, Thais ;

Di Stefano, Antonino ;

Ciprandi, Giorgio .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (02) :395-406

[68] Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction [J].

Rigas, Diamanda ;

Lewis, Gavin ;

Aron, Jennifer L. ;

Wang, Bowen ;

Banie, Homayon ;

Sankaranarayanan, Ishwarya ;

Galle-Treger, Lauriane ;

Maazi, Hadi ;

Lo, Richard ;

Freeman, Gordon J. ;

Sharpe, Arlene H. ;

Soroosh, Pejman ;

Akbari, Omid .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (05) :1468-+

[69]

Rosas-Salazar C., 2018, Journal of Allergy and Clinical Immunology

[70] Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence [J].

Rubner, Frederick J. ;

Jackson, Daniel J. ;

Evans, Michael D. ;

Gangnon, Ronald E. ;

Tisler, Christopher J. ;

Pappas, Tressa E. ;

Gern, James E. ;

Lemanske, Robert F., Jr. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (02) :501-507

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