Advances in asthma in 2017: Mechanisms, biologics, and genetics

被引：30
作者：
Grayson, Mitchell H. [1 ]
Feldman, Scott [2 ]
Prince, Benjamin T. [1 ]
Patel, Priya J. [2 ]
Matsui, Elizabeth C. [3 ]
Apter, Andrea J. [2 ]
机构：
[1] Ohio State Univ, Coll Med, Div Allergy & Immunol, Dept Pediat,Nationwide Childrens Hosp, Columbus, OH USA
[2] Univ Penn, Sch Med, Dept Med, Sect Allergy & Immunol,Div Pulm Allergy Crit Care, Philadelphia, PA 19104 USA
[3] Univ Texas Austin, Dept Populat Hlth, Dell Med Sch, Austin, TX 78712 USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2018年 / 142卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Asthma; airway hyperreactivity; asthma biomarkers; asthma phenotypes; genetics; environment; respiratory viruses; allergens; eosinophils; helper T cells; B cells; innate lymphoid cells; neutrophils; biologic therapies; microbiome; CHILDHOOD ASTHMA; POOLED ANALYSIS; DOUBLE-BLIND; AIRWAY; LUNG; SENSITIZATION; ADULTS; INTERVENTION; RISK; INFLAMMATION;
D O I：
10.1016/j.jaci.2018.08.033
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they can influence the clinical delivery of asthma care. After this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. Finally, we conclude with a discussion of advances in health literacy and how they will affect asthma care.
引用
收藏
页码：1423 / 1436
页数：14
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