Synthesis of an antitumor active endoperoxide from 11-keto-β-boswellic acid

被引：25
|
作者：
Csuk, Rene [1 ]
Niesen-Barthel, Anja [1 ]
Barthel, Alexander [1 ]
Kluge, Ralph [1 ]
Stroehl, Dieter [1 ]
机构：
[1] Univ Halle Wittenberg, Bereich Organ Chem, D-06120 Halle, Saale, Germany
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 09期
关键词：
11-keto-beta-boswellic acid; Antitumor activity; Endoperoxide; Apoptosis; NONSTEROIDAL ANTIINFLAMMATORY AGENT; BOSWELLIA-SERRATA; ACETYL-11-KETO-BETA-BOSWELLIC ACID; CELLS; APOPTOSIS; DERIVATIVES; ARTHRITIS; EXTRACT; HL-60;
D O I：
10.1016/j.ejmech.2010.05.036
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An endoperoxide was synthesized starting from 11-keto-beta-boswellic acid and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The compound induces apoptosis and shows an average IC(50) value of 0.4-4.5 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：3840 / 3843
页数：4
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