The human gut microbiome and health inequities

被引：109

作者：

Amato, Katherine R. ^{[1
]}

Arrieta, Marie-Claire ^{[2
,3
]}

Azad, Meghan B. ^{[4
,5
]}

Bailey, Michael T. ^{[6
,7
]}

Broussard, Josiane L. ^{[8
]}

Bruggeling, Carlijn E. ^{[9
]}

Claud, Erika C. ^{[10
]}

Costello, Elizabeth K. ^{[11
]}

Davenport, Emily R. ^{[12
]}

Dutilh, Bas E. ^{[13
,14
]}

Ewald, Holly A. Swain ^{[15
]}

Ewald, Paul ^{[15
]}

Hanlon, Erin C. ^{[16
]}

Julion, Wrenetha ^{[17
]}

Keshavarzian, Ali ^{[18
]}

Maurice, Corinne F. ^{[19
]}

Miller, Gregory E. ^{[20
,21
]}

Preidis, Geoffrey A. ^{[22
,23
]}

Segurel, Laure ^{[24
,30
]}

Singer, Burton ^{[25
]}

Subramanian, Sathish ^{[26
,27
]}

Zhao, Liping ^{[28
,29
]}

Kuzawa, Christopher W. ^{[1
,21
]}

机构：

[1] Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA

[2] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Dept Pediat, Calgary, AB T2N 4N1, Canada

[4] Childrens Hosp Res Inst Manitoba, Winnipeg, MB R3E 3P4, Canada

[5] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3A 1S1, Canada

[6] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Ctr Microbial Pathogenesis, Columbus, OH 43205 USA

[7] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA

[8] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80521 USA

[9] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6500 HB Nijmegen, Netherlands

[10] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

[11] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[12] Penn State Univ, Huck Inst Life Sci, Inst Computat & Data Sci, Dept Biol, University Pk, PA 16802 USA

[13] Univ Utrecht, Sci Life, Theoret Biol & Bioinformat, NL-3584 CH Utrecht, Netherlands

[14] Radboud Univ Nijmegen, Med Ctr, Ctr Mol & Biomol Informat, NL-6525 GA Nijmegen, Netherlands

[15] Univ Louisville, Dept Biol, Louisville, KY 40292 USA

[16] Univ Chicago, Dept Med, Sect Endocrinol Diabet & Metab, Chicago, IL 60637 USA

[17] Rush Univ, Coll Nursing, Chicago, IL 60612 USA

[18] Rush Univ, Med Ctr, Rush Ctr Integrated Microbiome & Chronobiol Res, Chicago, IL 60612 USA

[19] McGill Univ, Microbiol & Immunol Dept, Montreal, PQ H3A 2B4, Canada

[20] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA

[21] Northwestern Univ, Inst Policy Res, Evanston, IL 60208 USA

[22] Baylor Coll Med, Dept Pediat, Sect Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA

[23] Texas Childrens Hosp, Houston, TX 77030 USA

[24] Univ Paris, CNRS, Museum Natl Hist Nat, Ecoanthropol, F-75016 Paris, France

[25] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32608 USA

[26] Massachusetts Gen Hosp, Dept Med, Div Gastroenterol, Boston, MA 02114 USA

[27] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[28] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China

[29] Rutgers Univ New Brunswick, Rutgers New Jersey Inst Food Nutr & Hlth, Sch Environm & Biol Sci, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA

[30] Univ Lyon, Univ Lyon 1, CNRS, Lab Biornetrie & Biol Evolut,UMR5558, F-69622 Villeurbanne, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2021年 / 118卷 / 25期

关键词：

structural racism; health disparities; chronic disease; DOHad; policy; EARLY-LIFE; COLONIZATION RESISTANCE; INTESTINAL MICROBIOTA; SOCIOECONOMIC-STATUS; CHILDHOOD ASTHMA; IN-UTERO; INFANT; STRESS; CONSEQUENCES; ASSOCIATION;

D O I：

10.1073/pnas.2017947118

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Individuals who are minoritized as a result of race, sexual identity, gender, or socioeconomic status experience a higher prevalence of many diseases. Understanding the biological processes that cause and maintain these socially driven health inequities is essential for addressing them. The gut microbiome is strongly shaped by host environments and affects host metabolic, immune, and neuroendocrine functions, making it an important pathway by which differences in experiences caused by social, political, and economic forces could contribute to health inequities. Nevertheless, few studies have directly integrated the gut microbiome into investigations of health inequities. Here, we argue that accounting for host-gut microbe interactions will improve understanding and management of health inequities, and that health policy must begin to consider the microbiome as an important pathway linking environments to population health.

引用

页数：10

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