A neurodevelopmental model for anorexia nervosa

被引:162
作者
Connan, F
Campbell, IC
Katzman, M
Lightman, SL
Treasure, J
机构
[1] Bristol Royal Infirm & Gen Hosp, Dept Med, Bristol BS2 8HW, Avon, England
[2] Weill Cornell Med Ctr, New York, NY USA
[3] Inst Psychiat, Dept Psychol, London SE5 8AF, England
[4] Kings Coll London, Inst Psychiat, London SE5 8PF, England
关键词
anorexia nervosa; aetiology; developmental; attachment; HPA axis; chronic stress;
D O I
10.1016/S0031-9384(03)00101-X
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
This paper integrates genetic and biological data on aetiological risk for anorexia nervosa (AN) with cognitive and psychosocial explanatory models. We have reviewed clinical and basic science data from each of these domains and then used a developmental perspective to formulate a multifactorial threshold model. By positioning interpersonal stress as a central component of this model, psychological, social and biological conceptualisations of AN can be used to generate a data driven, neurodevelopmental hypothesis for the aetiology of this complex disorder. (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:13 / 24
页数:12
相关论文
共 155 条
  • [61] KAYE WH, 1991, ARCH GEN PSYCHIAT, V48, P556
  • [62] CSF 5-HIAA CONCENTRATIONS IN ANOREXIA-NERVOSA - REDUCED VALUES IN UNDERWEIGHT SUBJECTS NORMALIZE AFTER WEIGHT-GAIN
    KAYE, WH
    GWIRTSMAN, HE
    GEORGE, DT
    JIMERSON, DC
    EBERT, MH
    [J]. BIOLOGICAL PSYCHIATRY, 1988, 23 (01) : 102 - 105
  • [63] Kaye WH, 1997, PSYCHOPHARMACOL BULL, V33, P335
  • [64] KENDLER KS, 1991, AM J PSYCHIAT, V148, P1627
  • [65] Short-term estradiol treatment enhances pituitary-adrenal axis and sympathetic responses to psychosocial stress in healthy young men
    Kirschbaum, C
    Schommer, N
    Federenko, I
    Gaab, J
    Neumann, O
    Oellers, M
    Rohleder, N
    Untiedt, A
    Hanker, J
    Pirke, KM
    Hellhammer, DH
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (10) : 3639 - 3643
  • [66] EFFECTS OF THE GLUCOCORTICOID ANTAGONIST RU-486 ON PITUITARY-ADRENAL-FUNCTION IN PATIENTS WITH ANOREXIA-NERVOSA AND HEALTHY-VOLUNTEERS - ENHANCEMENT OF PLASMA ACTH AND CORTISOL SECRETION IN UNDERWEIGHT PATIENTS
    KLING, MA
    DEMITRACK, MA
    WHITFIELD, HJ
    KALOGERAS, KT
    LISTWAK, SJ
    DEBELLIS, MD
    CHROUSOS, GP
    GOLD, PW
    BRANDT, HA
    [J]. NEUROENDOCRINOLOGY, 1993, 57 (06) : 1082 - 1091
  • [67] Age differences in genetic and environmental influences on eating attitudes and behaviors in preadolescent and adolescent female twins
    Klump, KL
    McGue, M
    Iacono, WG
    [J]. JOURNAL OF ABNORMAL PSYCHOLOGY, 2000, 109 (02) : 239 - 251
  • [68] OBSERVATIONS ON THE ACTION OF AMPEROZIDE - ARE THERE SOCIAL INFLUENCES ON SOW-LITTER PRODUCTIVITY
    KYRIAKIS, SC
    OLSSON, NG
    MARTINSSON, K
    BJORK, AKK
    [J]. RESEARCH IN VETERINARY SCIENCE, 1991, 51 (02) : 169 - 173
  • [69] Lambe EK, 1997, ARCH GEN PSYCHIAT, V54, P537
  • [70] Lee S, 2001, INT J EAT DISORDER, V29, P224, DOI 10.1002/1098-108X(200103)29:2&lt