A neurodevelopmental model for anorexia nervosa

被引：162
作者：
Connan, F
Campbell, IC
Katzman, M
Lightman, SL
Treasure, J
机构：
[1] Bristol Royal Infirm & Gen Hosp, Dept Med, Bristol BS2 8HW, Avon, England
[2] Weill Cornell Med Ctr, New York, NY USA
[3] Inst Psychiat, Dept Psychol, London SE5 8AF, England
[4] Kings Coll London, Inst Psychiat, London SE5 8PF, England
来源：
PHYSIOLOGY & BEHAVIOR | 2003年 / 79卷 / 01期
关键词：
anorexia nervosa; aetiology; developmental; attachment; HPA axis; chronic stress;
D O I：
10.1016/S0031-9384(03)00101-X
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
This paper integrates genetic and biological data on aetiological risk for anorexia nervosa (AN) with cognitive and psychosocial explanatory models. We have reviewed clinical and basic science data from each of these domains and then used a developmental perspective to formulate a multifactorial threshold model. By positioning interpersonal stress as a central component of this model, psychological, social and biological conceptualisations of AN can be used to generate a data driven, neurodevelopmental hypothesis for the aetiology of this complex disorder. (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：13 / 24
页数：12
相关论文
共 155 条
  • [51] Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
    Heim, C
    Newport, DJ
    Heit, S
    Graham, YP
    Wilcox, M
    Bonsall, R
    Miller, AH
    Nemeroff, CB
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 284 (05): : 592 - 597
  • [52] The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: A multiple regression analysis
    Heim, C
    Newport, DJ
    Wagner, D
    Wilcox, MM
    Miller, AH
    Nemeroff, CB
    [J]. DEPRESSION AND ANXIETY, 2002, 15 (03) : 117 - 125
  • [53] The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
    Holsboer, F
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 1999, 33 (03) : 181 - 214
  • [54] THE RESPONSES OF PLASMA ADRENOCORTICOTROPIN AND CORTISOL TO CORTICOTROPIN-RELEASING HORMONE (CRH) AND CEREBROSPINAL-FLUID IMMUNOREACTIVE CRH IN ANOREXIA-NERVOSA PATIENTS
    HOTTA, M
    SHIBASAKI, T
    MASUDA, A
    IMAKI, T
    DEMURA, H
    LING, N
    SHIZUME, K
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (02) : 319 - 324
  • [55] Individual-specific risk factors for anorexia nervosa: a pilot study using a discordant sister-pair design
    Karwautz, A
    Rabe-Hesketh, S
    Hu, X
    Zhao, J
    Sham, P
    Collier, DA
    Treasure, JL
    [J]. PSYCHOLOGICAL MEDICINE, 2001, 31 (02) : 317 - 329
  • [56] Katzman MA, 1997, INT J EAT DISORDER, V22, P385, DOI 10.1002/(SICI)1098-108X(199712)22:4&lt
  • [57] 385::AID-EAT3&gt
  • [58] 3.0.CO
  • [59] 2-I
  • [60] ELEVATED CEREBROSPINAL-FLUID LEVELS OF IMMUNOREACTIVE CORTICOTROPIN-RELEASING HORMONE IN ANOREXIA-NERVOSA - RELATION TO STATE OF NUTRITION, ADRENAL-FUNCTION, AND INTENSITY OF DEPRESSION
    KAYE, WH
    GWIRTSMAN, HE
    GEORGE, DT
    EBERT, MH
    JIMERSON, DC
    TOMAI, TP
    CHROUSOS, GP
    GOLD, PW
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (02) : 203 - 208
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